PRR5 (Proline Rich 5)
A gene encoding a proline-rich protein involved in mTOR signaling and potential tumor suppression.
Gene Information Card
| Symbol | PRR5 |
|---|---|
| Full Name | Proline Rich 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 22q13.31 |
| NCBI Gene ID | 55615 ncbi.nlm.nih.gov/gene/55615 |
| Ensembl ID | ENSG00000100226 |
| UniProt ID | Q96M27 |
| OMIM ID | 614208 |
| HGNC ID | 25895 |
| Aliases | PROLINE-RICH PROTEIN 5, MGC13170 |
Description
PRR5 (Proline Rich 5) is a protein-coding gene located on chromosome 22q13.31. The encoded protein is a component of the mTORC2 complex and plays a role in cell growth, survival, and metabolism. PRR5 is also known as a potential tumor suppressor, with altered expression observed in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered PRR5 expression may affect mTORC2 signaling, influencing cell proliferation and survival. | COSMIC; ClinVar |
| Colorectal cancer | PRR5 mutations and expression changes reported, potentially impacting tumor progression. | COSMIC; NCBI Gene |
| Prostate cancer | PRR5 downregulation observed, possibly contributing to oncogenic signaling. | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Kidney | 4.1 | Low |
| Liver | 2.9 | Low |
| Lung | 3.5 | Low |
| Muscle | 2.1 | Low |
| Pancreas | 3.0 | Low |
| Spleen | 4.6 | Low |
| Testis | 6.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.5 | Embryonic kidney cells |
| HeLa | 3.2 | Cervical cancer cells |
| MCF7 | 2.8 | Breast cancer cells |
| A549 | 3.9 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T | Missense | <0.1% | p.Arg113Trp; potential functional impact |
| c.454G>A | Missense | <0.1% | p.Gly152Arg; reported in COSMIC |
| c.601_602del | Frameshift | <0.1% | Loss of function; truncation |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to loss of PRR5 function, potentially disrupting mTORC2 signaling.
Gain of Function (GOF)
No gain-of-function mutations currently documented.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • TORC2 complex (GO:0031932) |
| • positive regulation of GTPase activity (GO:0043547) | • cellular response to insulin stimulus (GO:0032869) |
Pathways
• mTOR signaling pathway (KEGG: hsa04150)
• PI3K-Akt signaling pathway (KEGG: hsa04151)
Protein Summary
The PRR5 protein is a proline-rich component of the mTORC2 complex, which phosphorylates AKT and regulates cell survival, metabolism, and cytoskeletal organization. It is expressed at low levels in most tissues and may function as a tumor suppressor.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRR5L Knockout HEK293 Cell Line | EDJ-KQ1193 | Human | 79899 | Details Get a Quote |
| PRR5L Knockout A-549 Cell Line | EDJ-KQ20494 | Human | 79899 | Details Get a Quote |
| PRR5L Knockout HeLa Cell Line | EDJ-KQ20495 | Human | 79899 | Details Get a Quote |
| PRR5 Knockout HEK293 Cell Line | EDJ-KQ51462 | Human | 55615 | Details Get a Quote |
| PRR5-ARHGAP8 Knockout HEK293 Cell Line | EDJ-KQ52369 | Human | 553158 | Details Get a Quote |
| PRR5 Knockout HeLa Cell Line | EDJ-KQ56611 | Human | 55615 | Details Get a Quote |
| PRR5-ARHGAP8 Knockout HeLa Cell Line | EDJ-KQ60504 | Human | 553158 | Details Get a Quote |
| PRR5 Knockout A-549 Cell Line | EDJ-KQ65110 | Human | 55615 | Details Get a Quote |
| PRR5-ARHGAP8 Knockout A-549 Cell Line | EDJ-KQ68974 | Human | 553158 | Details Get a Quote |
| PRR5 Knockout HCT 116 Cell Line | EDJ-KQ73556 | Human | 55615 | Details Get a Quote |
| PRR5L Knockout HCT 116 Cell Line | EDJ-KQ74187 | Human | 79899 | Details Get a Quote |
| PRR5-ARHGAP8 Knockout HCT 116 Cell Line | EDJ-KQ77332 | Human | 553158 | Details Get a Quote |
