PRDX6 Gene - Peroxiredoxin 6: Function, Disease Associations, and Expression
A comprehensive biomedical overview of PRDX6, a bifunctional enzyme with peroxidase and phospholipase A2 activities, its role in oxidative stress, diseases, and tissue expression.
Gene Information Card
| Symbol | PRDX6 |
|---|---|
| Full Name | Peroxiredoxin 6 |
| Gene Type | Protein coding |
| Chromosomal Location | 1q25.1 |
| NCBI Gene ID | 9588 ncbi.nlm.nih.gov/gene/9588 |
| Ensembl ID | ENSG00000117592 |
| UniProt ID | P30041 |
| OMIM ID | 602316 |
| HGNC ID | 16748 |
| Aliases | AOP2, KIAA0106, NSGPx, p29, PRX |
Description
PRDX6 encodes peroxiredoxin 6, a unique 1-Cys peroxiredoxin that exhibits both glutathione-dependent peroxidase activity and calcium-independent phospholipase A2 activity. It plays a critical role in redox regulation, phospholipid metabolism, and protection against oxidative stress. The protein is widely expressed and involved in various cellular processes including antioxidant defense, signal transduction, and membrane repair.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | PRDX6 overexpression promotes tumor growth and metastasis via its peroxidase and PLA2 activities, enhancing cell survival under oxidative stress. | COSMIC, PubMed |
| Neurodegenerative disorders | Altered PRDX6 expression contributes to oxidative damage in neurons; its PLA2 activity may influence lipid peroxidation and neuroinflammation. | PubMed |
| Cardiovascular diseases | PRDX6 protects against ischemia-reperfusion injury by reducing oxidative stress and modulating phospholipid remodeling. | PubMed |
| Inflammatory diseases | PRDX6 regulates inflammation through its PLA2 activity, affecting eicosanoid production and cytokine release. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | High | High |
| Liver | High | High |
| Kidney | Medium | Medium |
| Brain | Medium | Medium |
| Heart | Medium | Medium |
| Skeletal muscle | Low | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (Lung carcinoma) | High | Overexpressed in lung cancer cells |
| HepG2 (Liver carcinoma) | High | High expression in liver cells |
| HeLa (Cervical carcinoma) | Medium | Moderate expression |
| MCF7 (Breast carcinoma) | Medium | Moderate expression |
| SH-SY5Y (Neuroblastoma) | Low | Lower expression in neuronal cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1Val) | Missense | Rare | Potential loss of protein function |
| c.2T>C (p.Met1Thr) | Missense | Rare | Potential loss of protein function |
| c.3G>A (p.Met1Ile) | Missense | Rare | Potential loss of protein function |
| c.4A>G (p.Thr2Ala) | Missense | Rare | Unknown effect |
| c.5C>T (p.Thr2Met) | Missense | Rare | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
Mutations affecting the start codon (e.g., p.Met1Val) likely result in loss of protein expression or truncated non-functional protein, leading to reduced peroxidase and PLA2 activities.
Gain of Function (GOF)
No gain-of-function mutations have been reported in PRDX6; overexpression is observed in cancers but not due to mutations.
Dominant Negative (DN)
No dominant-negative mutations have been documented for PRDX6.
View complete mutation data：
Gene Ontology (GO)
| • Peroxidase activity | • Phospholipase A2 activity |
| • Oxidoreductase activity | • Response to oxidative stress |
| • Lipid metabolic process | • Cell redox homeostasis |
| • Apoptotic process | • Inflammatory response |
Pathways
• Reactive oxygen species (ROS) metabolism
• Phospholipid metabolism
• NF-kappaB signaling
• p53 signaling
• MAPK signaling
Protein Summary
PRDX6 is a 224-amino acid protein with a molecular weight of ~25 kDa. It contains a single conserved cysteine residue (Cys47) essential for its peroxidase activity, which reduces hydrogen peroxide and organic hydroperoxides using glutathione as an electron donor. Its PLA2 activity is calcium-independent and involved in membrane phospholipid remodeling. The protein is predominantly cytosolic but can translocate to membranes under oxidative stress. PRDX6 is implicated in various diseases, particularly cancer, where its overexpression correlates with poor prognosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDX6 Knockout SRA01/04 Cell Line | EDJ-KQ67 | Human | 9588 | Details Get a Quote |
| Prdx6 Knockout TM4 Cell Line | EDJ-KQ76 | Mouse | 11758 | Details Get a Quote |
| PRDX6 Knockout HEK293 Cell Line | EDJ-KQ1098 | Human | 9588 | Details Get a Quote |
| PRDX6 Knockout A-549 Cell Line | EDJ-KQ20270 | Human | 9588 | Details Get a Quote |
| PRDX6 Knockout HCT 116 Cell Line | EDJ-KQ20271 | Human | 9588 | Details Get a Quote |
| PRDX6 Knockout HeLa Cell Line | EDJ-KQ20272 | Human | 9588 | Details Get a Quote |
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