PRDX5: Peroxiredoxin 5 – Antioxidant Enzyme and Disease Implications
Comprehensive gene card for PRDX5, including expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | PRDX5 |
|---|---|
| Full Name | Peroxiredoxin 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 25824 ncbi.nlm.nih.gov/gene/25824 |
| Ensembl ID | ENSG00000126432 |
| UniProt ID | P30044 |
| OMIM ID | 606448 |
| HGNC ID | 9355 |
| Aliases | ACR1, AOEB166, B166, HEL-S-55, PLP, PMP20, PRDX6, PRXV, SBBI10, prx-V, thioredoxin peroxidase PMP20 |
Description
PRDX5 (peroxiredoxin 5) encodes a member of the peroxiredoxin family of antioxidant enzymes. This protein reduces hydrogen peroxide and alkyl hydroperoxides, protecting cells against oxidative stress. It is localized to mitochondria, peroxisomes, and the cytosol. PRDX5 is involved in redox signaling, apoptosis regulation, and has been implicated in various cancers and neurodegenerative diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression of PRDX5 may promote tumor cell survival by reducing oxidative stress-induced apoptosis. | PMID: 21947058 |
| Lung cancer | PRDX5 upregulation correlates with poor prognosis and resistance to chemotherapy. | PMID: 25695672 |
| Alzheimer's disease | PRDX5 is downregulated in affected brain regions, contributing to oxidative damage. | PMID: 17267542 |
| Atherosclerosis | PRDX5 protects against oxidative modification of LDL and endothelial dysfunction. | PMID: 18541561 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 28.5 | High |
| Liver | 22.3 | High |
| Kidney | 18.7 | Medium |
| Heart | 15.2 | Medium |
| Brain | 8.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 32.1 | Cervical cancer cell line |
| A549 | 29.8 | Lung adenocarcinoma cell line |
| HepG2 | 25.4 | Hepatocellular carcinoma cell line |
| MCF7 | 22.6 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.100C>T (p.Arg34Cys) | Missense | 0.01% | May alter enzyme activity; reported in ClinVar |
| c.202G>A (p.Gly68Ser) | Missense | 0.005% | Unknown functional impact |
| c.301A>G (p.Thr101Ala) | Missense | 0.02% | Likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PRDX5.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • peroxidase activity (GO:0004601) | • thioredoxin peroxidase activity (GO:0008379) |
| • mitochondrion (GO:0005739) | • peroxisome (GO:0005777) |
| • cytosol (GO:0005829) | • response to oxidative stress (GO:0006979) |
| • cell redox homeostasis (GO:0045454) |
Pathways
• Reactome: Detoxification of Reactive Oxygen Species (R-HSA-3299685)
• KEGG: Peroxiredoxin (hsa00480)
Protein Summary
Peroxiredoxin 5 (PRDX5) is a 214-amino acid antioxidant enzyme with a molecular weight of approximately 22 kDa. It contains a conserved Cys-47 residue essential for peroxidase activity. PRDX5 reduces H2O2, organic hydroperoxides, and peroxynitrite, using thioredoxin as an electron donor. It is widely expressed and plays a role in protecting cells from oxidative damage, modulating apoptosis, and influencing cancer progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDX5 Knockout HEK293 Cell Line | EDJ-KQ14891 | Human | 25824 | Details Get a Quote |
| PRDX5 Knockout A-549 Cell Line | EDJ-KQ45337 | Human | 25824 | Details Get a Quote |
| PRDX5 Knockout HCT 116 Cell Line | EDJ-KQ45338 | Human | 25824 | Details Get a Quote |
| PRDX5 Knockout HeLa Cell Line | EDJ-KQ45339 | Human | 25824 | Details Get a Quote |
| PRDX5 Knockout 22Rv1 Cell Line | EDJ-KZ413 | Human | 25824 | Details Get a Quote |
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