PRDX4: Peroxiredoxin 4 – Antioxidant Enzyme and ER Stress Regulator
Comprehensive gene card for PRDX4, including genomic data, expression, mutations, and disease associations.
Gene Information Card
| Symbol | PRDX4 |
|---|---|
| Full Name | Peroxiredoxin 4 |
| Gene Type | protein-coding |
| Chromosomal Location | Xp22.11 |
| NCBI Gene ID | 10549 ncbi.nlm.nih.gov/gene/10549 |
| Ensembl ID | ENSG00000123131 |
| UniProt ID | Q13162 |
| OMIM ID | 300312 |
| HGNC ID | 9353 |
| Aliases | AOE372, PRX-4, PrxIV, thioredoxin peroxidase 4 |
Description
PRDX4 encodes peroxiredoxin 4, a member of the peroxiredoxin family of antioxidant enzymes. It reduces hydrogen peroxide and organic hydroperoxides, and is localized to the endoplasmic reticulum (ER) where it plays a key role in redox regulation, protein folding, and protection against oxidative stress. PRDX4 is involved in ER stress response, cell signaling, and apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (breast, lung, prostate) | Overexpression of PRDX4 promotes tumor growth by reducing oxidative stress and inhibiting apoptosis; also linked to chemoresistance. | COSMIC, ClinVar, PubMed |
| Type 2 diabetes | PRDX4 deficiency in pancreatic beta cells leads to increased oxidative stress and impaired insulin secretion. | OMIM, PubMed |
| Neurodegenerative disorders (Alzheimer's, Parkinson's) | Dysregulation of PRDX4 contributes to oxidative damage and protein misfolding in neurons. | PubMed, ClinVar |
| Atherosclerosis | PRDX4 modulates endothelial function and vascular inflammation via redox signaling. | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | High |
| Kidney | 10.2 | High |
| Pancreas | 8.9 | Medium |
| Heart | 6.3 | Medium |
| Brain | 3.1 | Low |
| Lung | 7.8 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 (liver) | 14.1 | High expression |
| HEK293 (embryonic kidney) | 11.3 | Moderate expression |
| MCF7 (breast cancer) | 9.5 | Overexpressed in cancer |
| A549 (lung cancer) | 8.2 | Elevated |
| SH-SY5Y (neuroblastoma) | 4.0 | Low baseline |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.586C>T (p.Arg196Cys) | Missense | <0.01% | Reduced peroxidase activity; associated with increased oxidative stress |
| c.1A>G (p.Met1Val) | Start loss | <0.001% | Loss of protein expression; likely pathogenic |
| c.364G>A (p.Gly122Ser) | Missense | 0.02% | Altered substrate specificity; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Mutations such as p.Met1Val lead to complete loss of protein expression, impairing antioxidant defense.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PRDX4.
Dominant Negative (DN)
p.Arg196Cys may act in a dominant-negative manner by forming mixed disulfides with wild-type PRDX4, reducing overall activity.
View complete mutation data：
Gene Ontology (GO)
| • peroxidase activity (GO:0004601) | • thioredoxin peroxidase activity (GO:0008379) |
| • cytoplasm (GO:0005737) | • endoplasmic reticulum (GO:0005783) |
| • response to oxidative stress (GO:0006979) | • cell redox homeostasis (GO:0045454) |
| • peroxiredoxin activity (GO:0051920) |
Pathways
• hsa04141 – Protein processing in endoplasmic reticulum
• hsa04064 – NF-kappa B signaling pathway
• hsa04211 – Longevity regulating pathway
• hsa04931 – Insulin resistance
Protein Summary
Peroxiredoxin 4 (PRDX4) is a 271-amino acid antioxidant enzyme localized to the endoplasmic reticulum. It reduces H2O2 and organic hydroperoxides using thioredoxin as an electron donor. PRDX4 forms homodimers and contains a conserved Cys-Cys active site. It is critical for ER redox homeostasis, protein folding, and protection against oxidative damage. Dysregulation of PRDX4 is implicated in cancer, diabetes, and neurodegenerative diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDX4 Knockout HEK293 Cell Line | EDJ-KQ3662 | Human | 10549 | Details Get a Quote |
| PRDX4 Knockout A-549 Cell Line | EDJ-KQ25637 | Human | 10549 | Details Get a Quote |
| PRDX4 Knockout HCT 116 Cell Line | EDJ-KQ25638 | Human | 10549 | Details Get a Quote |
| PRDX4 Knockout HeLa Cell Line | EDJ-KQ25639 | Human | 10549 | Details Get a Quote |
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