PRDM4 Gene: PR Domain Zinc Finger Protein 4
Transcriptional regulator involved in cell differentiation and cancer
Gene Information Card
| Symbol | PRDM4 |
|---|---|
| Full Name | PR/SET domain 4 |
| Gene Type | protein-coding |
| Chromosomal Location | 12q23.3 |
| NCBI Gene ID | 11108 ncbi.nlm.nih.gov/gene/11108 |
| Ensembl ID | ENSG00000110848 |
| UniProt ID | Q9UKN5 |
| OMIM ID | 605731 |
| HGNC ID | 9348 |
| Aliases | PFM1, PR domain zinc finger protein 4 |
Description
PRDM4 (PR/SET domain 4) encodes a member of the PR domain family of transcriptional regulators. The protein contains an N-terminal PR domain (related to SET methyltransferase domains) and multiple C-terminal zinc finger motifs. PRDM4 functions as a transcription factor involved in cell differentiation, proliferation, and apoptosis. It is implicated in neurogenesis and cancer, where it may act as a tumor suppressor or oncogene depending on context.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PRDM4 expression is altered in breast tumors; may regulate cell cycle genes | PMID: 23455423 |
| Colorectal cancer | PRDM4 methylation and reduced expression linked to tumor progression | PMID: 25656847 |
| Neuroblastoma | PRDM4 promotes differentiation of neural progenitor cells | PMID: 21558396 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Lung | 9.7 | Low |
| Kidney | 7.4 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.5 | Embryonic kidney cells |
| HeLa | 8.9 | Cervical cancer cells |
| SH-SY5Y | 14.2 | Neuroblastoma cells |
| MCF7 | 7.3 | Breast cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | missense | 0.01% | p.Arg412Trp; unknown functional impact |
| c.567_568del | frameshift | <0.01% | Loss of function; truncation |
| c.890A>G | missense | 0.02% | p.Asn297Ser; possibly benign |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations predicted to cause loss of PRDM4 transcriptional activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Notch signaling pathway
• p53 signaling pathway
• Transcriptional misregulation in cancer
Protein Summary
PRDM4 is a 745-amino acid nuclear protein with a PR domain and six C2H2-type zinc fingers. It binds DNA and regulates transcription of genes involved in cell cycle and differentiation. The PR domain may mediate protein-protein interactions and chromatin remodeling. PRDM4 is expressed in multiple tissues, with highest levels in brain and testis. It interacts with proteins such as p53 and HDACs, influencing apoptosis and neurogenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PRDM4 Knockout HEK293 Cell Line | EDJ-KQ7288 | Human | 11108 | Details Get a Quote |
| PRDM4 Knockout A-549 Cell Line | EDJ-KQ32325 | Human | 11108 | Details Get a Quote |
| PRDM4 Knockout HCT 116 Cell Line | EDJ-KQ32326 | Human | 11108 | Details Get a Quote |
| PRDM4 Knockout HeLa Cell Line | EDJ-KQ32327 | Human | 11108 | Details Get a Quote |
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