PPP3R2
Protein Phosphatase 3 Regulatory Subunit B, Beta
Gene Information Card
| Symbol | PPP3R2 |
|---|---|
| Full Name | Protein Phosphatase 3 Regulatory Subunit B, Beta |
| Gene Type | protein-coding |
| Chromosomal Location | 9q31.1 |
| NCBI Gene ID | 5535 ncbi.nlm.nih.gov/gene/5535 |
| Ensembl ID | ENSG00000107099 |
| UniProt ID | Q96LZ3 |
| OMIM ID | 613821 |
| HGNC ID | 9317 |
| Aliases | CNB2, CALNB2, PPP3R2L |
Description
PPP3R2 encodes the beta regulatory subunit of calcineurin (protein phosphatase 3), a calcium/calmodulin-dependent serine/threonine phosphatase. This subunit binds calcium and modulates the catalytic activity of the calcineurin A subunit. Calcineurin is involved in T-cell activation, cardiac hypertrophy, and neuronal signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | N/A | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Skeletal Muscle | 5.4 | Low |
| Kidney | 4.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 9.3 | Low |
| K562 | 7.1 | Low |
| HeLa | 6.8 | Low |
| HepG2 | 5.9 | Low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding | • calmodulin binding |
| • protein phosphatase regulator activity | • calcineurin complex |
| • cytoplasm | • nucleus |
Pathways
• Calcineurin-regulated NFAT signaling
• Calcium signaling pathway
Protein Summary
PPP3R2 (calcineurin B beta) is a 170-amino acid regulatory subunit that binds four calcium ions and associates with the catalytic A subunit to form the active calcineurin heterodimer. It is essential for calcineurin phosphatase activity and downstream signaling, including NFAT dephosphorylation and nuclear translocation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP3R2 Knockout HEK293 Cell Line | EDJ-KQ1414 | Human | 5535 | Details Get a Quote |
| PPP3R2 Knockout HeLa Cell Line | EDJ-KQ54196 | Human | 5535 | Details Get a Quote |
| PPP3R2 Knockout A-549 Cell Line | EDJ-KQ62691 | Human | 5535 | Details Get a Quote |
| PPP3R2 Knockout HCT 116 Cell Line | EDJ-KQ71161 | Human | 5535 | Details Get a Quote |
