PPP2R5B
Protein Phosphatase 2 Regulatory Subunit B' Beta
Gene Information Card
| Symbol | PPP2R5B |
|---|---|
| Full Name | Protein Phosphatase 2 Regulatory Subunit B' Beta |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 5526 ncbi.nlm.nih.gov/gene/5526 |
| Ensembl ID | ENSG00000110367 |
| UniProt ID | Q15173 |
| OMIM ID | 601643 |
| HGNC ID | 9310 |
| Aliases | B56B, B56beta, PP2A B subunit B56-beta, PR61B |
Description
PPP2R5B encodes a regulatory subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase involved in cell cycle regulation, signal transduction, and apoptosis. The B' (B56) beta subunit modulates substrate specificity and subcellular localization of the PP2A holoenzyme.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered PP2A activity due to PPP2R5B dysregulation may affect tumor suppressor pathways | PMID: 25605274 |
| Lung cancer | PPP2R5B overexpression linked to poor prognosis and altered cell proliferation | PMID: 29187737 |
| Intellectual disability | De novo missense variants in PPP2R5B associated with neurodevelopmental disorders | ClinVar: RCV001091234 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 10.5 | Embryonic kidney |
| HeLa | 8.9 | Cervical carcinoma |
| A549 | 7.2 | Lung carcinoma |
| MCF7 | 11.3 | Breast carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.107C>T (p.Pro36Leu) | Missense | <0.01% | Altered PP2A binding |
| c.458G>A (p.Arg153Gln) | Missense | <0.01% | De novo, associated with intellectual disability |
| c.1123A>G (p.Thr375Ala) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Missense variants reducing PP2A holoenzyme assembly or phosphatase activity.
Gain of Function (GOF)
Not well documented; overexpression in some cancers may confer gain-of-function effects.
Dominant Negative (DN)
Some variants may interfere with wild-type subunit incorporation into PP2A complexes.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000159 - protein phosphatase type 2A complex | • GO:0005515 - protein binding |
| • GO:0008601 - protein phosphatase regulator activity | • GO:0019901 - protein kinase binding |
| • GO:0042802 - identical protein binding |
Pathways
• hsa04110 - Cell cycle
• hsa04115 - p53 signaling pathway
• hsa04010 - MAPK signaling pathway
• hsa04310 - Wnt signaling pathway
Protein Summary
PPP2R5B encodes the B56 beta regulatory subunit of PP2A, a 527-amino acid protein that directs PP2A to specific substrates. It contains a B56 domain essential for substrate recognition and holoenzyme assembly. The protein is widely expressed, with highest levels in brain and testis, and plays roles in cell cycle control, apoptosis, and signal transduction.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP2R5B Knockout HEK293 Cell Line | EDJ-KQ270 | Human | 5526 | Details Get a Quote |
| PPP2R5B Knockout A-549 Cell Line | EDJ-KQ19652 | Human | 5526 | Details Get a Quote |
| PPP2R5B Knockout HCT 116 Cell Line | EDJ-KQ19654 | Human | 5526 | Details Get a Quote |
| PPP2R5B Knockout HeLa Cell Line | EDJ-KQ19655 | Human | 5526 | Details Get a Quote |
| PPP2R5B Knockout HAP1 Cell Line | EDC08317 | Human | 5526 | Details Get a Quote |
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