PPP2R5A
Protein Phosphatase 2 Regulatory Subunit B' Alpha
Gene Information Card
| Symbol | PPP2R5A |
|---|---|
| Full Name | Protein Phosphatase 2 Regulatory Subunit B' Alpha |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.3 |
| NCBI Gene ID | 5525 ncbi.nlm.nih.gov/gene/5525 |
| Ensembl ID | ENSG00000142507 |
| UniProt ID | Q15172 |
| OMIM ID | 601643 |
| HGNC ID | 9309 |
| Aliases | B56alpha, PR61A, PP2A-B56alpha |
Description
PPP2R5A encodes the B56alpha regulatory subunit of protein phosphatase 2A (PP2A), a major serine/threonine phosphatase involved in cell cycle regulation, signal transduction, and apoptosis. The B56alpha subunit directs PP2A holoenzyme substrate specificity and subcellular localization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered PP2A activity due to PPP2R5A dysregulation may affect tumor suppressor pathways | PMID: 23431171 |
| Lung cancer | PPP2R5A expression changes linked to cell proliferation control | PMID: 25605248 |
| Neurodevelopmental disorders | De novo missense variants in PPP2R5A associated with intellectual disability | ClinVar: RCV000626015 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Heart | 8.7 | Low |
| Liver | 6.3 | Low |
| Kidney | 11.4 | Medium |
| Testis | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression |
| HeLa | 12.3 | Medium expression |
| A549 | 9.8 | Low expression |
| MCF7 | 14.7 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96Gln) | Missense | <0.01% | Altered substrate binding |
| c.1015C>T (p.Arg339Trp) | Missense | <0.01% | Reduced PP2A activity |
| c.1246_1248del (p.Lys416del) | In-frame deletion | <0.01% | Impaired holoenzyme assembly |
Mutation functional classification
Loss of Function (LOF)
Missense variants in the HEAT repeat domain reduce binding to the PP2A catalytic subunit, decreasing phosphatase activity.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Some variants may act dominant-negative by sequestering catalytic subunit into non-functional complexes.
View complete mutation data：
Gene Ontology (GO)
| • GO:0000159 - protein phosphatase type 2A complex | • GO:0005515 - protein binding |
| • GO:0008601 - protein phosphatase regulator activity | • GO:0007049 - cell cycle |
| • GO:0043066 - negative regulation of apoptotic process |
Pathways
• PP2A-mediated dephosphorylation (Reactome: R-HSA-163615)
• Signaling by Wnt (Reactome: R-HSA-195721)
• MAPK signaling (KEGG: hsa04010)
Protein Summary
PPP2R5A encodes the B56alpha regulatory subunit of PP2A, a 56 kDa protein containing HEAT repeats that mediate interaction with the PP2A core enzyme. It targets PP2A to specific substrates such as AKT, p53, and beta-catenin, regulating cell growth and survival.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP2R5A Knockout HEK293 Cell Line | EDJ-KQ855 | Human | 5525 | Details Get a Quote |
| PPP2R5A Knockout A-549 Cell Line | EDJ-KQ19649 | Human | 5525 | Details Get a Quote |
| PPP2R5A Knockout HCT 116 Cell Line | EDJ-KQ19650 | Human | 5525 | Details Get a Quote |
| PPP2R5A Knockout HeLa Cell Line | EDJ-KQ19651 | Human | 5525 | Details Get a Quote |
| PPP2R5A Knockout HAP1 Cell Line | EDC08093 | Human | 5525 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
