PPP2R3B Gene - Protein Phosphatase 2 Regulatory Subunit B''Beta
A regulatory subunit of protein phosphatase 2A (PP2A) involved in cell cycle control and tumor suppression.
Gene Information Card
| Symbol | PPP2R3B |
|---|---|
| Full Name | Protein Phosphatase 2 Regulatory Subunit B''Beta |
| Gene Type | Protein coding |
| Chromosomal Location | Xp22.33 |
| NCBI Gene ID | 28227 ncbi.nlm.nih.gov/gene/28227 |
| Ensembl ID | ENSG00000165272 |
| UniProt ID | Q9Y5P4 |
| OMIM ID | 300468 |
| HGNC ID | 9309 |
| Aliases | PR72, PPP2R3, PP2A PR72 subunit |
Description
PPP2R3B encodes a regulatory subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in cell cycle regulation, signal transduction, and tumor suppression. The B''beta subunit targets PP2A to specific substrates, influencing processes such as Wnt signaling and DNA damage response.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung cancer | Altered PP2A activity due to PPP2R3B mutations may disrupt cell cycle control | COSMIC, ClinVar |
| Breast cancer | Dysregulation of PP2A complexes involving PPP2R3B contributes to oncogenic signaling | COSMIC |
| Colorectal cancer | Loss of PPP2R3B expression associated with tumor progression | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 12.5 | Medium |
| Skeletal muscle | 10.2 | Medium |
| Brain | 8.1 | Low |
| Lung | 7.3 | Low |
| Liver | 5.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Embryonic kidney, high expression |
| HeLa | 9.8 | Cervical cancer, moderate expression |
| A549 | 7.2 | Lung cancer, low expression |
| MCF7 | 6.5 | Breast cancer, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.1% | Loss of function, truncated protein |
| c.567G>A (p.Glu189Lys) | Missense | 0.2% | Unknown significance |
| c.890_891insA | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations lead to truncated or absent protein, reducing PP2A regulatory activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
Not documented.
View complete mutation data：
Gene Ontology (GO)
Pathways
• hsa04110 - Cell cycle
• hsa04310 - Wnt signaling pathway
• hsa05200 - Pathways in cancer
Protein Summary
PPP2R3B encodes the B''beta regulatory subunit of protein phosphatase 2A (PP2A). This subunit directs PP2A to specific substrates, modulating cell cycle progression, Wnt signaling, and DNA repair. Mutations or altered expression of PPP2R3B are implicated in several cancers, including lung, breast, and colorectal cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP2R3B Knockout HEK293 Cell Line | EDJ-KQ51219 | Human | 28227 | Details Get a Quote |
| PPP2R3B Knockout HeLa Cell Line | EDJ-KQ56070 | Human | 28227 | Details Get a Quote |
| PPP2R3B Knockout A-549 Cell Line | EDJ-KQ64554 | Human | 28227 | Details Get a Quote |
| PPP2R3B Knockout HCT 116 Cell Line | EDJ-KQ73012 | Human | 28227 | Details Get a Quote |
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