PPP2R3A Gene - Protein Phosphatase 2 Regulatory Subunit B'' Alpha
A regulatory subunit of protein phosphatase 2A (PP2A) involved in cell cycle control and tumor suppression.
Gene Information Card
| Symbol | PPP2R3A |
|---|---|
| Full Name | Protein Phosphatase 2 Regulatory Subunit B'' Alpha |
| Gene Type | protein-coding |
| Chromosomal Location | 3q27.1 |
| NCBI Gene ID | 5523 ncbi.nlm.nih.gov/gene/5523 |
| Ensembl ID | ENSG00000163874 |
| UniProt ID | Q06190 |
| OMIM ID | 603113 |
| HGNC ID | 9307 |
| Aliases | PR72, PPP2R3, B''alpha |
Description
PPP2R3A encodes a regulatory subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase that regulates diverse cellular processes including cell cycle progression, DNA replication, and signal transduction. The B'' regulatory subunit confers substrate specificity and subcellular localization. PPP2R3A is implicated in cancer and developmental disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | Altered PP2A activity due to PPP2R3A mutations may disrupt cell cycle control | COSMIC, ClinVar |
| Breast Cancer | Loss of PPP2R3A expression correlates with poor prognosis | NCBI, literature |
| Intellectual Disability | De novo missense variants in PPP2R3A associated with neurodevelopmental phenotypes | ClinVar, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Heart | 8.2 | Medium |
| Brain | 6.1 | Low |
| Liver | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.3 | High expression |
| HeLa | 9.8 | Medium expression |
| A549 | 7.1 | Medium expression |
| MCF7 | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01 | Unknown |
| c.789_790del (p.Glu264fs) | Frameshift | <0.001 | Loss of function |
| c.1567G>A (p.Glu523Lys) | Missense | <0.01 | Unknown |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense variants predicted to truncate the protein, leading to loss of PP2A regulatory function.
Gain of Function (GOF)
Not reported for PPP2R3A.
Dominant Negative (DN)
Missense variants in the binding domain may interfere with PP2A complex assembly.
View complete mutation data：
Gene Ontology (GO)
| • protein phosphatase regulator activity | • protein binding |
| • cell cycle | • signal transduction |
Pathways
• PP2A-mediated dephosphorylation
• Cell cycle - G1/S transition
• Wnt signaling pathway
Protein Summary
PPP2R3A encodes the B'' regulatory subunit of PP2A (PR72). The protein contains a calcium-binding EF-hand domain and mediates PP2A substrate specificity. It is involved in dephosphorylation of key cell cycle regulators such as CDK1 and p53. Alternative splicing generates multiple isoforms.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP2R3A Knockout HEK293 Cell Line | EDJ-KQ854 | Human | 5523 | Details Get a Quote |
| PPP2R3A Knockout A-549 Cell Line | EDJ-KQ19646 | Human | 5523 | Details Get a Quote |
| PPP2R3A Knockout HCT 116 Cell Line | EDJ-KQ19647 | Human | 5523 | Details Get a Quote |
| PPP2R3A Knockout HeLa Cell Line | EDJ-KQ19648 | Human | 5523 | Details Get a Quote |
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