PPP1R37
Protein Phosphatase 1 Regulatory Subunit 37
Gene Information Card
| Symbol | PPP1R37 |
|---|---|
| Full Name | Protein Phosphatase 1 Regulatory Subunit 37 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | Q8WUR7 |
| OMIM ID | 617811 |
| HGNC ID | 24942 |
| Aliases | FLJ10305, MGC138290 |
Description
PPP1R37 encodes a regulatory subunit of protein phosphatase 1 (PP1), a serine/threonine phosphatase involved in diverse cellular processes including cell cycle regulation, glycogen metabolism, and signal transduction. The protein binds to PP1 catalytic subunits and directs them to specific substrates or subcellular compartments.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 3.1 | Low |
| Heart | 2.8 | Low |
| Kidney | 2.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 10.3 | Moderate expression |
| K562 | 6.7 | Low expression |
| HepG2 | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Trp) | Missense | <0.01% (gnomAD) | Unknown functional effect |
| c.567delA (p.Glu190fs) | Frameshift | <0.001% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations likely lead to nonsense-mediated decay or truncated protein, impairing PP1 targeting.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • protein phosphatase 1 binding | • protein phosphatase regulator activity |
| • cytoplasm | • nucleus |
Pathways
• PP1 regulatory network
• Glycogen metabolism
Protein Summary
PPP1R37 is a 612-amino acid protein containing a PP1-binding motif (RVxF) that mediates interaction with PP1 catalytic subunits. It is widely expressed with highest levels in testis. The protein may play roles in spermatogenesis and cellular signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP1R37 Knockout HEK293 Cell Line | EDJ-KQ14861 | Human | 284352 | Details Get a Quote |
| PPP1R37 Knockout HCT 116 Cell Line | EDJ-KQ44042 | Human | 284352 | Details Get a Quote |
| PPP1R37 Knockout A-549 Cell Line | EDJ-KQ45310 | Human | 284352 | Details Get a Quote |
| PPP1R37 Knockout HeLa Cell Line | EDJ-KQ45312 | Human | 284352 | Details Get a Quote |
| PPP1R37 Knockout HAP1 Cell Line | EDC07998 | Human | 284352 | Details Get a Quote |
Displaying Records 1 To 5 Of 5 Records
