PPP1R26
Protein Phosphatase 1 Regulatory Subunit 26
Gene Information Card
| Symbol | PPP1R26 |
|---|---|
| Full Name | Protein Phosphatase 1 Regulatory Subunit 26 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.13 |
| NCBI Gene ID | 440356 ncbi.nlm.nih.gov/gene/440356 |
| Ensembl ID | ENSG00000165029 |
| UniProt ID | Q5VWQ8 |
| OMIM ID | 616448 |
| HGNC ID | 24913 |
| Aliases | KIAA0649, PPP1R26, FLJ10154 |
Description
PPP1R26 encodes a regulatory subunit of protein phosphatase 1 (PP1), which is involved in various cellular processes including cell cycle regulation, glycogen metabolism, and signal transduction. The protein contains a PP1-binding motif and may target PP1 to specific substrates.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered PP1 regulation may affect cell cycle and growth control | COSMIC somatic mutations observed |
| No specific Mendelian disease reported | Not applicable | OMIM no phenotype association |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Liver | 5.1 | Low |
| Kidney | 4.3 | Low |
| Heart | 3.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 10.2 | Moderate expression |
| K562 | 7.8 | Low expression |
| HepG2 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412*) | Nonsense | <0.01% | Loss of function |
| c.567G>A (p.Glu189Lys) | Missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations predicted to cause premature truncation and loss of PP1 regulatory function.
Gain of Function (GOF)
No evidence for gain-of-function mutations.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein phosphatase 1 binding | • protein phosphatase regulator activity |
| • cytoplasm | • nucleus |
Pathways
• PP1 regulatory network
• Glycogen metabolism
Protein Summary
PPP1R26 is a 1107-amino acid protein that acts as a regulatory subunit of protein phosphatase 1. It contains a PP1-binding motif and is expressed in multiple tissues, with highest levels in testis. The protein may target PP1 to specific subcellular locations or substrates, influencing processes such as cell cycle progression and metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP1R26 Knockout HEK293 Cell Line | EDJ-KQ6786 | Human | 9858 | Details Get a Quote |
| PPP1R26 Knockout A-549 Cell Line | EDJ-KQ31255 | Human | 9858 | Details Get a Quote |
| PPP1R26 Knockout HCT 116 Cell Line | EDJ-KQ31256 | Human | 9858 | Details Get a Quote |
| PPP1R26 Knockout HeLa Cell Line | EDJ-KQ31257 | Human | 9858 | Details Get a Quote |
