PPP1R16B Gene
Protein Phosphatase 1 Regulatory Subunit 16B
Gene Information Card
| Symbol | PPP1R16B |
|---|---|
| Full Name | Protein Phosphatase 1 Regulatory Subunit 16B |
| Gene Type | Protein coding |
| Chromosomal Location | 20q11.23 |
| NCBI Gene ID | 26051 ncbi.nlm.nih.gov/gene/26051 |
| Ensembl ID | ENSG00000101447 |
| UniProt ID | Q96T60 |
| OMIM ID | 610792 |
| HGNC ID | 14944 |
| Aliases | TIMAP, PPP1R16B, FLJ11273 |
Description
PPP1R16B (Protein Phosphatase 1 Regulatory Subunit 16B) is a protein coding gene located on chromosome 20q11.23. It encodes a regulatory subunit of protein phosphatase 1 (PP1) that targets PP1 to specific subcellular compartments and modulates its activity. The protein is involved in cell signaling, cytoskeletal organization, and endothelial barrier function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | N/A | N/A |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Heart | 8.9 | Medium |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | Moderate expression |
| HeLa | 12.3 | Moderate expression |
| A549 | 18.7 | Higher expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • GO:0004864 - protein phosphatase inhibitor activity | • GO:0005515 - protein binding |
| • GO:0005737 - cytoplasm | • GO:0005829 - cytosol |
| • GO:0016020 - membrane | • GO:0030154 - cell differentiation |
Pathways
• Protein phosphatase 1 regulatory network
• Endothelial barrier regulation
Protein Summary
PPP1R16B encodes a 567-amino acid protein (UniProt Q96T60) that functions as a regulatory subunit of protein phosphatase 1 (PP1). It contains a PP1-binding motif and an ankyrin repeat domain, mediating interactions with cytoskeletal and signaling proteins. The protein is implicated in maintaining endothelial cell barrier integrity and regulating actin dynamics.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPP1R16B Knockout HEK293 Cell Line | EDJ-KQ8371 | Human | 26051 | Details Get a Quote |
| PPP1R16B Knockout HeLa Cell Line | EDJ-KQ55876 | Human | 26051 | Details Get a Quote |
| PPP1R16B Knockout A-549 Cell Line | EDJ-KQ64365 | Human | 26051 | Details Get a Quote |
| PPP1R16B Knockout HCT 116 Cell Line | EDJ-KQ72816 | Human | 26051 | Details Get a Quote |
| PPP1R16B Knockout HAP1 Cell Line | EDC08172 | Human | 26051 | Details Get a Quote |
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