PPME1
Protein Phosphatase Methylesterase 1
Gene Information Card
| Symbol | PPME1 |
|---|---|
| Full Name | Protein Phosphatase Methylesterase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 51400 ncbi.nlm.nih.gov/gene/51400 |
| Ensembl ID | ENSG00000137710 |
| UniProt ID | O95352 |
| OMIM ID | 610174 |
| HGNC ID | 30137 |
| Aliases | PME-1, PP2A methylesterase, MGC133046 |
Description
PPME1 encodes a protein phosphatase methylesterase that specifically demethylates the catalytic subunit of protein phosphatase 2A (PP2A). This demethylation regulates PP2A activity and is implicated in cell cycle control, growth signaling, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | PPME1 overexpression leads to PP2A inactivation, promoting oncogenic signaling | COSMIC, literature |
| Glioblastoma | PPME1 upregulation correlates with poor prognosis and PP2A demethylation | PubMed, COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Lung | 8.7 | Low |
| Liver | 6.3 | Low |
| Kidney | 10.1 | Medium |
| Testis | 20.5 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.4 | Embryonic kidney |
| HeLa | 18.9 | Cervical cancer |
| A549 | 9.3 | Lung cancer |
| U87MG | 22.1 | Glioblastoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | missense | <0.1% | Unknown functional impact |
| c.544C>T (p.Arg182Trp) | missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Overexpression is associated with oncogenic gain-of-function in cancer.
Dominant Negative (DN)
No dominant negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • protein methylesterase activity | • protein phosphatase regulator activity |
| • cytoplasm | • nucleus |
| • protein demethylation |
Pathways
• PP2A methylation/demethylation cycle
• Regulation of cell cycle
• MAPK signaling
Protein Summary
PPME1 is a 42 kDa protein that specifically demethylates the PP2A catalytic subunit at leucine 309, modulating PP2A holoenzyme assembly and activity. It is overexpressed in several cancers and considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPME1 Knockout HEK293 Cell Line | EDJ-KQ11088 | Human | 51400 | Details Get a Quote |
| PPME1 Knockout A-549 Cell Line | EDJ-KQ39028 | Human | 51400 | Details Get a Quote |
| PPME1 Knockout HCT 116 Cell Line | EDJ-KQ39029 | Human | 51400 | Details Get a Quote |
| PPME1 Knockout HeLa Cell Line | EDJ-KQ37726 | Human | 51400 | Details Get a Quote |
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