PPIG (Peptidylprolyl Isomerase G)
Cyclophilin G, a peptidyl-prolyl cis-trans isomerase involved in protein folding and pre-mRNA splicing
Gene Information Card
| Symbol | PPIG |
|---|---|
| Full Name | Peptidylprolyl Isomerase G |
| Gene Type | protein-coding |
| Chromosomal Location | 2q31.1 |
| NCBI Gene ID | 9360 ncbi.nlm.nih.gov/gene/9360 |
| Ensembl ID | ENSG00000138311 |
| UniProt ID | Q9Y3C6 |
| OMIM ID | 606093 |
| HGNC ID | 9360 |
| Aliases | CYP60, SRCyp |
Description
PPIG encodes a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The protein catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, facilitating protein folding. It also contains a serine/arginine (SR)-rich domain and is involved in pre-mRNA splicing as a component of the spliceosome. PPIG is widely expressed and has been implicated in viral replication and cancer biology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | PPIG overexpression may promote cell proliferation and splicing dysregulation | PMID: 31289472 |
| Breast cancer | Altered PPIG expression linked to splicing factor network changes | PMID: 29395067 |
| HIV-1 infection | PPIG interacts with HIV-1 integrase and modulates viral replication | PMID: 19141480 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 28.5 | High |
| Lymph node | 22.1 | High |
| Spleen | 20.3 | High |
| Brain | 12.4 | Medium |
| Liver | 8.7 | Medium |
| Heart | 6.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 25.0 | Embryonic kidney, high expression |
| HeLa | 22.3 | Cervical carcinoma, high expression |
| HepG2 | 18.7 | Hepatocellular carcinoma, medium expression |
| MCF7 | 15.2 | Breast cancer, medium expression |
| K562 | 10.5 | Leukemia, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Ile) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.452A>G (p.Asn151Ser) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.784G>A (p.Glu262Lys) | Missense | <0.01% | Unknown; rare variant in population databases |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PPIG.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PPIG.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported in PPIG.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Spliceosome (Reactome: R-HSA-72163)
• Processing of Capped Intron-Containing Pre-mRNA (Reactome: R-HSA-72203)
• mRNA Splicing - Major Pathway (Reactome: R-HSA-72163)
Protein Summary
PPIG encodes cyclophilin G, a 754-amino acid protein with an N-terminal peptidylprolyl isomerase domain and a C-terminal SR-rich domain. It localizes to the nucleus and cytoplasm, catalyzes proline isomerization, and participates in pre-mRNA splicing as part of the spliceosome. The protein interacts with HIV-1 integrase and is overexpressed in certain cancers, suggesting roles in viral replication and tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PPIG Knockout HEK293 Cell Line | EDJ-KQ6558 | Human | 9360 | Details Get a Quote |
| PPIG Knockout HCT 116 Cell Line | EDJ-KQ29410 | Human | 9360 | Details Get a Quote |
| PPIG Knockout A-549 Cell Line | EDJ-KQ30759 | Human | 9360 | Details Get a Quote |
| PPIG Knockout HeLa Cell Line | EDJ-KQ30761 | Human | 9360 | Details Get a Quote |
