POSTN (Periostin) Gene: Structure, Function, and Clinical Significance
Comprehensive biomedical resource on the POSTN gene, including genomic data, expression, mutations, and associated diseases.
Gene Information Card
| Symbol | POSTN |
|---|---|
| Full Name | Periostin |
| Gene Type | Protein coding |
| Chromosomal Location | 13q13.3 |
| NCBI Gene ID | 10631 ncbi.nlm.nih.gov/gene/10631 |
| Ensembl ID | ENSG00000133110 |
| UniProt ID | Q15063 |
| OMIM ID | 608777 |
| HGNC ID | 16953 |
| Aliases | OSF-2, OSF2, PDLPOSTN, PN |
Description
POSTN encodes periostin, a secreted extracellular matrix protein that functions in cell adhesion, tissue remodeling, and wound healing. It is highly expressed in collagen-rich tissues and is implicated in fibrosis, cancer progression, and cardiovascular disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | Periostin is upregulated in airway epithelial cells and subepithelial fibroblasts, promoting subepithelial fibrosis and Th2 inflammation. | ClinVar, NCBI |
| Myocardial infarction | Elevated periostin expression in cardiac fibroblasts post-infarction contributes to collagen deposition and scar formation. | NCBI, OMIM |
| Non-small cell lung cancer | Overexpression of POSTN in tumor stroma correlates with invasion and poor prognosis via integrin signaling. | COSMIC, NCBI |
| Ovarian cancer | Periostin enhances tumor cell adhesion and metastasis through activation of Akt/PKB pathway. | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 27.8 | High |
| Lung | 15.2 | Medium |
| Kidney | 12.1 | Medium |
| Breast | 8.5 | Low |
| Liver | 3.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 22.5 | High expression |
| MCF7 (breast cancer) | 6.8 | Moderate expression |
| HepG2 (liver cancer) | 2.1 | Low expression |
| K562 (leukemia) | 0.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional effect |
| c.567_568insA (p.Glu190Argfs*12) | Frameshift | <0.01% | Predicted loss of function |
| c.789G>A (p.Trp263*) | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations are predicted to cause loss of function via nonsense-mediated decay or truncated protein.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in POSTN.
Dominant Negative (DN)
No evidence of dominant-negative effects for POSTN mutations.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion | • extracellular matrix organization |
| • integrin binding | • heparin binding |
| • osteoblast differentiation |
Pathways
• Integrin signaling pathway
• PI3K-Akt signaling pathway
• ECM-receptor interaction
• Focal adhesion
Protein Summary
Periostin is a 90 kDa secreted protein containing an EMI domain and four fasciclin-like domains. It binds integrins (αvβ3, αvβ5) and functions as a matricellular protein modulating cell migration, adhesion, and collagen fibrillogenesis. It is a key mediator in tissue repair and pathological fibrosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| POSTN Knockout HEK293 Cell Line | EDJ-KQ377 | Human | 10631 | Details Get a Quote |
| POSTN Knockout HeLa Cell Line | EDJ-KQ55448 | Human | 10631 | Details Get a Quote |
| POSTN Knockout A-549 Cell Line | EDJ-KQ63930 | Human | 10631 | Details Get a Quote |
| POSTN Knockout HCT 116 Cell Line | EDJ-KQ72387 | Human | 10631 | Details Get a Quote |
