POC1B-GALNT4 Readthrough Gene: A Novel Chimeric Transcript in Human Genomics
Comprehensive genomic, expression, and clinical insights into the POC1B-GALNT4 readthrough locus
Gene Information Card
| Symbol | POC1B-GALNT4 |
|---|---|
| Full Name | POC1B-GALNT4 readthrough (NMD candidate) |
| Gene Type | Readthrough (chimeric transcript) |
| Chromosomal Location | 12q21.33 (POC1B) and 12q21.33 (GALNT4) – adjacent genes on chromosome 12 |
| NCBI Gene ID | 100528024 ncbi.nlm.nih.gov/gene/100528024 |
| Ensembl ID | ENSG00000258839 |
| UniProt ID | Not applicable (no protein product; NMD candidate) |
| OMIM ID | Not assigned (readthrough locus) |
| HGNC ID | HGNC:44123 |
| Aliases | POC1B-GALNT4 readthrough transcript, POC1B-GALNT4 fusion |
Description
POC1B-GALNT4 is a readthrough gene locus that produces a chimeric transcript spanning the adjacent POC1B (POC1 centriolar protein B) and GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4) genes on chromosome 12q21.33. This readthrough transcript is predicted to be a nonsense-mediated decay (NMD) candidate, meaning it likely does not produce a functional protein. The locus is annotated in major genomic databases, but its biological significance remains under investigation. The readthrough event may represent a regulatory mechanism or a byproduct of transcriptional noise, with potential implications in gene expression regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established; readthrough transcript may be involved in NMD regulation, but no direct disease link has been reported. | No clinical evidence in ClinVar or OMIM for this specific readthrough locus. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| No data available | N/A | No tissue expression data (nTPM) available for the readthrough transcript; expression of individual genes POC1B and GALNT4 may be found separately. |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | N/A | No cell line expression data for the readthrough transcript; individual gene expression may be inferred from POC1B and GALNT4. |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No curated variants | N/A | N/A | No variants specifically curated for the readthrough locus in ClinVar or COSMIC. |
Mutation functional classification
Loss of Function (LOF)
Not applicable; no functional protein product.
Gain of Function (GOF)
Not applicable; no functional protein product.
Dominant Negative (DN)
Not applicable; no functional protein product.
View complete mutation data：
Protein Summary
The POC1B-GALNT4 readthrough transcript is predicted to undergo nonsense-mediated decay, and therefore no protein product is expected. The individual genes POC1B and GALNT4 encode proteins involved in centriole function and protein glycosylation, respectively, but the readthrough transcript itself does not contribute to these functions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| POC1B-GALNT4 Knockout HEK293 Cell Line | EDJ-KQ52487 | Human | 100528030 | Details Get a Quote |
| POC1B-GALNT4 Knockout HeLa Cell Line | EDJ-KQ60950 | Human | 100528030 | Details Get a Quote |
| POC1B-GALNT4 Knockout A-549 Cell Line | EDJ-KQ69425 | Human | 100528030 | Details Get a Quote |
| POC1B-GALNT4 Knockout HCT 116 Cell Line | EDJ-KQ77776 | Human | 100528030 | Details Get a Quote |
