PNOC (Prepronociceptin) Gene
Comprehensive gene card for PNOC, encoding the precursor for nociceptin and related neuropeptides.
Gene Information Card
| Symbol | PNOC |
|---|---|
| Full Name | Prepronociceptin |
| Gene Type | protein-coding |
| Chromosomal Location | 8p21.1 |
| NCBI Gene ID | 5368 ncbi.nlm.nih.gov/gene/5368 |
| Ensembl ID | ENSG00000168081 |
| UniProt ID | Q13519 |
| OMIM ID | 601459 |
| HGNC ID | 9163 |
| Aliases | NOC, OFQ, PPNOC, N/OFQ, Nociceptin |
Description
The PNOC gene encodes prepronociceptin, a precursor protein that is proteolytically processed to generate multiple neuropeptides, including nociceptin (also known as orphanin FQ), nocistatin, and other peptides. Nociceptin is the endogenous ligand for the nociceptin receptor (OPRL1), which modulates pain perception, stress responses, anxiety, and reward pathways. PNOC is expressed primarily in the central nervous system and plays a role in nociception, learning, and memory.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Chronic Pain | Altered nociceptin signaling modulates pain perception; PNOC polymorphisms may influence pain sensitivity. | ClinVar, NCBI |
| Anxiety Disorders | Nociceptin/OPRL1 system regulates stress and anxiety; PNOC expression changes observed in animal models. | NCBI, OMIM |
| Substance Use Disorder | Nociceptin modulates reward pathways; PNOC variants associated with addiction susceptibility. | NCBI, OMIM |
| Alzheimer's Disease | Dysregulation of PNOC expression in brain regions affected by Alzheimer's pathology. | NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | High |
| Spinal cord | 8.3 | Medium |
| Adrenal gland | 4.1 | Low |
| Testis | 2.7 | Low |
| Heart | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression |
| U-87 MG (glioblastoma) | 6.8 | Moderate expression |
| HEK293 (embryonic kidney) | 0.3 | Low/not detected |
| HepG2 (hepatocellular carcinoma) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; effect unknown |
| c.274C>T (p.Arg92Trp) | missense | <0.01% | Rare variant; functional impact not characterized |
| c.388G>A (p.Val130Ile) | missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Nociceptin/OPRL1 signaling (Reactome: R-HSA-418594)
• Neuropeptide signaling pathway (KEGG: hsa04080)
• GPCR downstream signaling (Reactome: R-HSA-388396)
Protein Summary
Prepronociceptin (UniProt Q13519) is a 176-amino acid precursor protein that is cleaved to produce nociceptin (orphanin FQ), a 17-amino acid neuropeptide, along with other peptides such as nocistatin. Nociceptin binds specifically to the nociceptin receptor (OPRL1), a G-protein-coupled receptor, to modulate pain, anxiety, and reward. The protein is predominantly expressed in the central nervous system and is involved in synaptic transmission and neuroendocrine regulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PNOC Knockout HEK293 Cell Line | EDJ-KQ3018 | Human | 5368 | Details Get a Quote |
| PNOC Knockout HeLa Cell Line | EDJ-KQ54163 | Human | 5368 | Details Get a Quote |
| PNOC Knockout A-549 Cell Line | EDJ-KQ62659 | Human | 5368 | Details Get a Quote |
| PNOC Knockout HCT 116 Cell Line | EDJ-KQ71126 | Human | 5368 | Details Get a Quote |
