PNLIPRP2
Pancreatic Lipase Related Protein 2
Gene Information Card
| Symbol | PNLIPRP2 |
|---|---|
| Full Name | Pancreatic Lipase Related Protein 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 10q25.3 |
| NCBI Gene ID | 5408 ncbi.nlm.nih.gov/gene/5408 |
| Ensembl ID | ENSG00000115594 |
| UniProt ID | P54315 |
| OMIM ID | 604423 |
| HGNC ID | 9156 |
| Aliases | PLRP2, PNLIPRP2 |
Description
PNLIPRP2 encodes pancreatic lipase related protein 2, a member of the pancreatic lipase gene family. This enzyme is involved in dietary lipid digestion, specifically hydrolyzing triglycerides, phospholipids, and galactolipids. It is expressed in the pancreas and plays a role in neonatal fat digestion and in conditions of pancreatic insufficiency.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatitis | Altered lipase activity may contribute to pancreatic inflammation | ClinVar, OMIM |
| Pancreatic Cancer | Dysregulation of PNLIPRP2 expression observed in pancreatic ductal adenocarcinoma | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 68.5 | High |
| Salivary Gland | 3.2 | Low |
| Stomach | 1.1 | Low |
| Small Intestine | 0.8 | Not detected |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 | 12.4 | Pancreatic cancer cell line |
| MIA PaCa-2 | 8.7 | Pancreatic cancer cell line |
| BxPC-3 | 15.1 | Pancreatic cancer cell line |
| HeLa | 0.2 | Cervical cancer cell line, low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.331C>T (p.Arg111Cys) | Missense | Rare | Unknown functional effect |
| c.758G>A (p.Arg253His) | Missense | Rare | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; no confirmed loss-of-function variants reported in ClinVar.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Dietary lipid digestion and absorption (Reactome: R-HSA-192456)
• Lipid digestion
• mobilization
• and transport (KEGG: hsa04975)
Protein Summary
Pancreatic lipase related protein 2 (PLRP2) is a 469-amino acid secreted enzyme with a molecular weight of approximately 52 kDa. It contains a conserved lipase domain and requires colipase for full activity. Unlike classical pancreatic lipase, PLRP2 exhibits broader substrate specificity, including phospholipids and galactolipids. It is particularly important for lipid digestion in neonates and in conditions of pancreatic insufficiency.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PNLIPRP2 Knockout HEK293 Cell Line | EDJ-KQ5498 | Human | 5408 | Details Get a Quote |
| PNLIPRP2 Knockout HCT 116 Cell Line | EDJ-KQ27484 | Human | 5408 | Details Get a Quote |
| PNLIPRP2 Knockout A-549 Cell Line | EDJ-KQ28731 | Human | 5408 | Details Get a Quote |
| PNLIPRP2 Knockout HeLa Cell Line | EDJ-KQ28733 | Human | 5408 | Details Get a Quote |
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