PLPPR5
Phospholipid Phosphatase Related 5
Gene Information Card
| Symbol | PLPPR5 |
|---|---|
| Full Name | Phospholipid Phosphatase Related 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p34.3 |
| NCBI Gene ID | 163404 ncbi.nlm.nih.gov/gene/163404 |
| Ensembl ID | ENSG00000162614 |
| UniProt ID | Q8NEB5 |
| OMIM ID | 616011 |
| HGNC ID | 26235 |
| Aliases | LPPR5, PRG-5, PRG5 |
Description
PLPPR5 (Phospholipid Phosphatase Related 5) is a protein-coding gene located on chromosome 1p34.3. It encodes a member of the phospholipid phosphatase-related protein family, which is involved in lipid metabolism and cell signaling. The protein is predicted to be a transmembrane protein with phosphatase activity, though its exact function is not fully characterized. PLPPR5 is expressed in various tissues, with notable levels in the brain and testis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 15.2 | Medium |
| Testis | 10.5 | Medium |
| Lung | 5.3 | Low |
| Heart | 3.1 | Low |
| Liver | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 12.8 | Neuroblastoma cell line |
| HEK 293 | 8.4 | Embryonic kidney cells |
| HeLa | 4.7 | Cervical cancer cells |
| A549 | 3.2 | Lung carcinoma cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported mutations in COSMIC or ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • phosphatidic acid phosphatase activity | • integral component of membrane |
| • lipid metabolic process |
Pathways
• Glycerophospholipid metabolism
Protein Summary
The PLPPR5 protein is a 316-amino acid transmembrane protein with a predicted molecular weight of 35.5 kDa. It contains a phosphatase domain and is involved in lipid dephosphorylation. Its exact biological role remains under investigation, but it is thought to modulate cell signaling through lipid metabolism.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLPPR5 Knockout HEK293 Cell Line | EDJ-KQ14064 | Human | 163404 | Details Get a Quote |
| PLPPR5 Knockout HeLa Cell Line | EDJ-KQ58859 | Human | 163404 | Details Get a Quote |
| PLPPR5 Knockout A-549 Cell Line | EDJ-KQ67350 | Human | 163404 | Details Get a Quote |
| PLPPR5 Knockout HCT 116 Cell Line | EDJ-KQ75741 | Human | 163404 | Details Get a Quote |
