PLPP2 (Phospholipid Phosphatase 2)
A key regulator of lipid metabolism and cell signaling, encoded by the PLPP2 gene.
Gene Information Card
| Symbol | PLPP2 |
|---|---|
| Full Name | Phospholipid Phosphatase 2 |
| Gene Type | Protein-coding |
| Chromosomal Location | 19p13.3 |
| NCBI Gene ID | 8613 ncbi.nlm.nih.gov/gene/8613 |
| Ensembl ID | ENSG00000104879 |
| UniProt ID | O43688 |
| OMIM ID | 607372 |
| HGNC ID | 9223 |
| Aliases | PAP2c, PPAP2C |
Description
PLPP2 encodes phospholipid phosphatase 2, an integral membrane protein that dephosphorylates phosphatidic acid, lysophosphatidic acid, and sphingosine-1-phosphate. This enzyme regulates lipid signaling and metabolism, influencing cell proliferation, differentiation, and migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered PLPP2 expression may disrupt lipid signaling pathways, promoting tumor growth and metastasis. | COSMIC; literature review |
| Metabolic disorders | Dysregulation of phospholipid metabolism linked to obesity and insulin resistance. | OMIM; literature review |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Medium |
| Brain | 5.1 | Low |
| Heart | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Hepatocellular carcinoma cell line |
| HEK293 | 10.2 | Embryonic kidney cell line |
| MCF7 | 6.8 | Breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.500G>A | Missense | <0.1% | p.Arg167His; potential loss of function |
| c.743C>T | Nonsense | <0.1% | p.Gln248*; truncation, likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Missense and nonsense mutations reduce phosphatase activity, impairing lipid signaling.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • phosphatidic acid phosphatase activity | • lysophosphatidic acid phosphatase activity |
| • sphingosine-1-phosphate phosphatase activity | • integral component of membrane |
| • lipid metabolic process | • signal transduction |
Pathways
• Glycerophospholipid metabolism
• Sphingolipid signaling pathway
Protein Summary
PLPP2 is a 311-amino acid transmembrane protein with three conserved domains. It catalyzes the dephosphorylation of bioactive lipids, modulating cell signaling. The protein is localized to the plasma membrane and endoplasmic reticulum.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLPP2 Knockout HEK293 Cell Line | EDJ-KQ1713 | Human | 8612 | Details Get a Quote |
| PLPP2 Knockout HCT 116 Cell Line | EDJ-KQ20198 | Human | 8612 | Details Get a Quote |
| PLPP2 Knockout A-549 Cell Line | EDJ-KQ21549 | Human | 8612 | Details Get a Quote |
| PLPP2 Knockout HeLa Cell Line | EDJ-KQ21551 | Human | 8612 | Details Get a Quote |
