PLK2 (Polo Like Kinase 2) Gene
A serine/threonine-protein kinase involved in cell cycle regulation, centriole duplication, and synaptic plasticity.
Gene Information Card
| Symbol | PLK2 |
|---|---|
| Full Name | Polo Like Kinase 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 5q11.2 |
| NCBI Gene ID | 10769 ncbi.nlm.nih.gov/gene/10769 |
| Ensembl ID | ENSG00000145632 |
| UniProt ID | Q9NYY3 |
| OMIM ID | 607023 |
| HGNC ID | 9077 |
| Aliases | SNK, hPlk2, polo-like kinase 2 |
Description
PLK2 (Polo Like Kinase 2) encodes a serine/threonine-protein kinase belonging to the CDC5/Polo subfamily. It is involved in cell cycle progression, particularly in centriole duplication and mitotic entry. PLK2 also plays roles in synaptic plasticity, neuronal differentiation, and response to DNA damage. Its expression is regulated in a cell cycle-dependent manner and is frequently altered in various cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (multiple types) | Dysregulation of PLK2 expression and activity contributes to uncontrolled cell proliferation and genomic instability. | COSMIC; NCBI Gene |
| Neurodegenerative disorders (e.g., Alzheimer's disease) | PLK2 modulates tau phosphorylation and synaptic function; altered expression linked to pathology. | NCBI Gene; UniProt |
| Developmental disorders | Rare variants in PLK2 have been associated with intellectual disability and microcephaly. | ClinVar; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Lymph node | 6.1 | Low |
| Liver | 2.4 | Low |
| Heart | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 15.2 | High expression in cervical cancer cell line |
| HEK293 | 10.1 | Moderate expression in embryonic kidney cells |
| SH-SY5Y | 18.7 | High expression in neuroblastoma cell line |
| MCF7 | 7.5 | Moderate expression in breast cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1012C>T (p.Arg338Trp) | Missense | <0.01% | Unknown; reported in ClinVar as variant of uncertain significance |
| c.1456G>A (p.Glu486Lys) | Missense | <0.01% | Unknown; reported in ClinVar as variant of uncertain significance |
| c.1789_1790insA (p.Thr597Asnfs*5) | Frameshift | <0.01% | Predicted loss of function; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations in PLK2 are predicted to result in truncated or absent protein, leading to loss of kinase activity and impaired centriole duplication.
Gain of Function (GOF)
Missense mutations in the kinase domain may increase catalytic activity, potentially driving oncogenic signaling; however, specific gain-of-function variants are not well characterized.
Dominant Negative (DN)
Certain missense mutations in the polo-box domain may interfere with substrate binding and exert dominant-negative effects on cell cycle regulation.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Cell Cycle (Reactome: R-HSA-1640170)
• Mitotic G1-G1/S phases (Reactome: R-HSA-453279)
• Centrosome maturation (Reactome: R-HSA-380270)
• PLK2-mediated phosphorylation of tau (UniProt)
Protein Summary
PLK2 is a 685-amino acid serine/threonine kinase with an N-terminal kinase domain and a C-terminal polo-box domain. It localizes to centrosomes and is essential for centriole duplication. PLK2 phosphorylates substrates such as CEP192, CEP152, and tau. Its activity is tightly regulated during the cell cycle, and it is implicated in tumor suppression and neuronal function.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLK2 Knockout HEK293 Cell Line | EDJ-KQ1537 | Human | 10769 | Details Get a Quote |
| PLK2 Knockout A-549 Cell Line | EDJ-KQ21198 | Human | 10769 | Details Get a Quote |
| PLK2 Knockout HCT 116 Cell Line | EDJ-KQ21199 | Human | 10769 | Details Get a Quote |
| PLK2 Knockout HeLa Cell Line | EDJ-KQ21200 | Human | 10769 | Details Get a Quote |
