PLGRKT (Plasminogen Receptor, C-Terminal Lysine Transmembrane Protein)
Gene encoding a transmembrane plasminogen receptor involved in fibrinolysis and cell migration
Gene Information Card
| Symbol | PLGRKT |
|---|---|
| Full Name | Plasminogen Receptor, C-Terminal Lysine Transmembrane Protein |
| Gene Type | Protein coding |
| Chromosomal Location | 9p24.2 |
| NCBI Gene ID | 55848 ncbi.nlm.nih.gov/gene/55848 |
| Ensembl ID | ENSG00000107104 |
| UniProt ID | Q9HBL0 |
| OMIM ID | 617258 |
| HGNC ID | 30087 |
| Aliases | MDS030, C9orf46, PLG-RKT |
Description
PLGRKT encodes a transmembrane protein that functions as a receptor for plasminogen. The C-terminal lysine residue binds plasminogen, facilitating its activation to plasmin, which plays a key role in fibrinolysis, extracellular matrix degradation, and cell migration. The gene is located on chromosome 9p24.2 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | PLGRKT overexpression enhances plasminogen activation, promoting tumor cell invasion and metastasis | COSMIC, literature |
| Thrombotic disorders | Altered PLGRKT function may impair fibrinolysis, increasing thrombosis risk | ClinVar, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 10.3 | Medium |
| Bone marrow | 8.7 | Low |
| Liver | 6.1 | Low |
| Kidney | 5.4 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.2 | High expression |
| HeLa | 9.8 | Moderate expression |
| K562 | 7.1 | Low expression |
| A549 | 11.4 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Synonymous | <0.01% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • actin cytoskeleton (GO:0015629) | • plasma membrane (GO:0005886) |
| • plasminogen binding (GO:0031639) | • fibrinolysis (GO:0042730) |
| • positive regulation of cell migration (GO:0030335) |
Pathways
• Plasminogen activating cascade
• Fibrinolysis pathway
Protein Summary
PLGRKT is a 147-amino acid transmembrane protein with a single C-terminal lysine residue essential for plasminogen binding. It localizes to the plasma membrane and promotes plasmin generation, influencing fibrinolysis and cell motility. UniProt ID: Q9HBL0.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLGRKT Knockout HEK293 Cell Line | EDJ-KQ14803 | Human | 55848 | Details Get a Quote |
| PLGRKT Knockout HeLa Cell Line | EDJ-KQ43968 | Human | 55848 | Details Get a Quote |
| PLGRKT Knockout A-549 Cell Line | EDJ-KQ45227 | Human | 55848 | Details Get a Quote |
| PLGRKT Knockout HCT 116 Cell Line | EDJ-KQ45228 | Human | 55848 | Details Get a Quote |
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