PLGLB2
Plasminogen-like B2
Gene Information Card
| Symbol | PLGLB2 |
|---|---|
| Full Name | plasminogen-like B2 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p11.2 |
| NCBI Gene ID | 5342 ncbi.nlm.nih.gov/gene/5342 |
| Ensembl ID | ENSG00000162931 |
| UniProt ID | Q02325 |
| OMIM ID | 173420 |
| HGNC ID | 9072 |
| Aliases | PLGL, PLGLA, PLGLB1 |
Description
PLGLB2 (plasminogen-like B2) is a protein-coding gene located on chromosome 2p11.2. It encodes a member of the plasminogen family, which is involved in fibrinolysis and extracellular matrix remodeling. The protein contains kringle domains and a serine protease domain but lacks proteolytic activity due to critical active site substitutions. PLGLB2 is expressed in various tissues and has been implicated in cancer and inflammatory processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may influence tumor invasion and metastasis through modulation of the plasminogen activation system. | COSMIC, NCBI Gene |
| Inflammatory disorders | Potential role in extracellular matrix degradation and immune cell migration. | UniProt, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 8.3 | Low |
| Lung | 6.1 | Low |
| Placenta | 15.2 | Medium |
| Heart | 4.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 14.0 | Hepatocellular carcinoma cell line |
| A549 | 7.5 | Lung adenocarcinoma cell line |
| HEK293 | 5.2 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234G>A | missense | <0.1% | Unknown functional impact |
| c.567C>T | synonymous | <0.1% | No predicted effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity | • kringle domain |
| • extracellular region | • fibrinolysis |
| • proteolysis |
Pathways
• Plasminogen activation cascade
• Fibrinolysis pathway
Protein Summary
The PLGLB2 protein is a 91 kDa glycoprotein containing five kringle domains and a serine protease domain. Despite structural similarity to plasminogen, it lacks proteolytic activity due to substitutions in the catalytic triad (His, Asp, Ser). It may function as a competitive inhibitor or modulator of plasminogen activation. The protein is secreted and localizes to the extracellular matrix.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLGLB2 Knockout HEK293 Cell Line | EDJ-KQ50516 | Human | 5342 | Details Get a Quote |
| PLGLB2 Knockout HeLa Cell Line | EDJ-KQ54154 | Human | 5342 | Details Get a Quote |
| PLGLB2 Knockout A-549 Cell Line | EDJ-KQ62649 | Human | 5342 | Details Get a Quote |
| PLGLB2 Knockout HCT 116 Cell Line | EDJ-KQ71117 | Human | 5342 | Details Get a Quote |
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