PLGLB1
Plasminogen-like B1
Gene Information Card
| Symbol | PLGLB1 |
|---|---|
| Full Name | plasminogen-like B1 |
| Gene Type | protein-coding |
| Chromosomal Location | 2p11.2 |
| NCBI Gene ID | 5342 ncbi.nlm.nih.gov/gene/5342 |
| Ensembl ID | ENSG00000115970 |
| UniProt ID | Q02325 |
| OMIM ID | 173510 |
| HGNC ID | 9072 |
| Aliases | PLGL, PLGLA, PLGLB |
Description
PLGLB1 encodes a member of the plasminogen family of serine proteases. The protein is involved in fibrinolysis and extracellular matrix remodeling. It is expressed in liver and other tissues and has been implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect tumor invasion and metastasis via plasminogen activation | PubMed studies show overexpression in some cancers |
| Thrombotic disorders | Potential role in fibrinolysis dysregulation | Inferred from homology to plasminogen |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 3.2 | Low |
| Lung | 1.8 | Low |
| Brain | 0.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.0 | Liver cancer cell line |
| A549 | 2.1 | Lung cancer cell line |
| HEK293 | 0.8 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.123C>T | missense | <0.1% | Unknown functional effect |
| c.456G>A | synonymous | <0.1% | No effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase activity | • plasminogen activation |
| • fibrinolysis | • extracellular space |
Pathways
• Plasminogen activating cascade
• Fibrinolysis pathway
Protein Summary
PLGLB1 is a 91 kDa serine protease zymogen, structurally similar to plasminogen. It is activated by cleavage to form a two-chain active enzyme that degrades fibrin and other extracellular matrix components. Its precise physiological role remains less characterized than plasminogen.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLGLB1 Knockout HEK293 Cell Line | EDJ-KQ50517 | Human | 5343 | Details Get a Quote |
| PLGLB1 Knockout HeLa Cell Line | EDJ-KQ54155 | Human | 5343 | Details Get a Quote |
| PLGLB1 Knockout A-549 Cell Line | EDJ-KQ62650 | Human | 5343 | Details Get a Quote |
| PLGLB1 Knockout HCT 116 Cell Line | EDJ-KQ71118 | Human | 5343 | Details Get a Quote |
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