PLEK2: Pleckstrin 2
A cytoskeletal adaptor protein involved in cell spreading and migration
Gene Information Card
| Symbol | PLEK2 |
|---|---|
| Full Name | pleckstrin 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 14q23.3 |
| NCBI Gene ID | 26499 ncbi.nlm.nih.gov/gene/26499 |
| Ensembl ID | ENSG00000100811 |
| UniProt ID | Q9NYT0 |
| OMIM ID | 608007 |
| HGNC ID | 19237 |
| Aliases | FLJ14007, MGC138211 |
Description
PLEK2 (pleckstrin 2) encodes a protein containing a pleckstrin homology (PH) domain. It localizes to the plasma membrane and actin cytoskeleton, promoting cell spreading and migration by regulating Rac1 activity and actin polymerization. PLEK2 is implicated in cancer progression and immune cell function.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung adenocarcinoma | Overexpression promotes cell proliferation and invasion via PI3K/Akt pathway | PMID: 31209456 |
| Breast cancer | Upregulation correlates with poor prognosis and metastasis | PMID: 32015523 |
| Colorectal cancer | High expression associated with tumor growth and migration | PMID: 30589842 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.1 | Medium |
| Spleen | 20.7 | High |
| Bone marrow | 18.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung cancer) | 22.1 | High expression |
| MCF7 (breast cancer) | 9.8 | Moderate expression |
| HCT116 (colon cancer) | 16.5 | High expression |
| K562 (leukemia) | 25.3 | Very high expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.497C>T (p.Thr166Met) | Missense | <0.01% | Unknown functional impact |
| c.103G>A (p.Glu35Lys) | Missense | <0.01% | Predicted benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in PLEK2.
Gain of Function (GOF)
Overexpression in cancers suggests potential gain-of-function role in tumorigenesis.
Dominant Negative (DN)
Not described for PLEK2.
View complete mutation data：
Gene Ontology (GO)
| • actin cytoskeleton organization | • cell migration |
| • cell spreading | • Rac1 protein signal transduction |
| • phosphatidylinositol binding |
Pathways
• PI3K-Akt signaling pathway
• Rac1 signaling
• Regulation of actin cytoskeleton
Protein Summary
Pleckstrin 2 is a 352-amino acid protein with a single PH domain that binds phosphatidylinositol lipids. It acts as a scaffold linking membrane signals to actin remodeling, facilitating cell motility and adhesion. Overexpressed in several cancers, it is considered a potential therapeutic target.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLEK2 Knockout HEK293 Cell Line | EDJ-KQ8530 | Human | 26499 | Details Get a Quote |
| PLEK2 Knockout A-549 Cell Line | EDJ-KQ34664 | Human | 26499 | Details Get a Quote |
| PLEK2 Knockout HCT 116 Cell Line | EDJ-KQ34665 | Human | 26499 | Details Get a Quote |
| PLEK2 Knockout HeLa Cell Line | EDJ-KQ34666 | Human | 26499 | Details Get a Quote |
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