PLCL2: Phospholipase C Like 2
A gene encoding a phospholipase C-related protein involved in immune signaling and cancer.
Gene Information Card
| Symbol | PLCL2 |
|---|---|
| Full Name | Phospholipase C Like 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 3p24.3 |
| NCBI Gene ID | 23228 ncbi.nlm.nih.gov/gene/23228 |
| Ensembl ID | ENSG00000154803 |
| UniProt ID | Q9UPQ0 |
| OMIM ID | 608665 |
| HGNC ID | 9063 |
| Aliases | PLCE2, PLC-L2, PLCL2a, PLCL2b |
Description
PLCL2 encodes a phospholipase C-like protein that lacks catalytic activity but may regulate intracellular signaling by competing with phospholipase C enzymes. It is involved in immune cell activation, particularly in B-cell receptor signaling, and has been implicated in autoimmune diseases and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Systemic lupus erythematosus | PLCL2 variants may alter B-cell receptor signaling, contributing to autoimmunity. | GWAS association (PMID: 21706007) |
| Rheumatoid arthritis | Polymorphisms in PLCL2 are linked to increased risk. | GWAS (PMID: 24390342) |
| Breast cancer | PLCL2 expression changes may influence tumor progression. | Expression studies (PMID: 25691885) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Whole blood | 8.2 | Low |
| Brain | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K-562 | 15.3 | Leukemia cell line |
| HEK 293 | 6.7 | Embryonic kidney |
| MCF7 | 4.2 | Breast cancer |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.01% | Unknown functional impact |
| c.567_569del | In-frame deletion | <0.01% | May affect protein stability |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare truncating variants may reduce protein expression.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase C activity | • signal transduction |
| • calcium ion binding | • plasma membrane |
Pathways
• B cell receptor signaling pathway
• Phospholipase C signaling
Protein Summary
PLCL2 is a 130 kDa protein that shares homology with phospholipase C but lacks catalytic residues. It is thought to modulate signaling by interacting with G proteins and receptors, particularly in immune cells. Expression is highest in lymphoid tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLCL2 Knockout HEK293 Cell Line | EDJ-KQ7898 | Human | 23228 | Details Get a Quote |
| PLCL2 Knockout HCT 116 Cell Line | EDJ-KQ32172 | Human | 23228 | Details Get a Quote |
| PLCL2 Knockout A-549 Cell Line | EDJ-KQ33499 | Human | 23228 | Details Get a Quote |
| PLCL2 Knockout HeLa Cell Line | EDJ-KQ33501 | Human | 23228 | Details Get a Quote |
