PLAAT5: Phospholipase A and Acyltransferase 5
A phospholipid-metabolizing enzyme with roles in membrane remodeling and potential links to cancer and neurological disorders
Gene Information Card
| Symbol | PLAAT5 |
|---|---|
| Full Name | Phospholipase A and Acyltransferase 5 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q12.3 |
| NCBI Gene ID | 201562 ncbi.nlm.nih.gov/gene/201562 |
| Ensembl ID | ENSG00000149269 |
| UniProt ID | Q6P1A2 |
| OMIM ID | 614607 |
| HGNC ID | 24961 |
| Aliases | HRASLS5, HRLP5, PLA2G16, AdPLA2 |
Description
PLAAT5 (Phospholipase A and Acyltransferase 5) encodes a member of the HRAS-like suppressor family. The protein exhibits both phospholipase A1/A2 and acyltransferase activities, catalyzing the hydrolysis and reacylation of phospholipids. It is involved in membrane phospholipid remodeling, lipid metabolism, and may play a role in adipocyte differentiation and tumor suppression. The gene is located on chromosome 11q12.3 and is expressed in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered expression may affect phospholipid signaling and cell proliferation; potential tumor suppressor role | COSMIC; literature |
| Neurological disorders | Dysregulation of phospholipid metabolism may impact neuronal membrane function | UniProt; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 15.2 | Medium |
| Brain | 8.5 | Low |
| Lung | 12.1 | Medium |
| Liver | 6.3 | Low |
| Kidney | 9.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 10.5 | Moderate expression |
| HeLa | 7.8 | Low expression |
| A549 | 11.2 | Medium expression |
| SH-SY5Y | 9.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.347C>T (p.Thr116Met) | Missense | <0.01% | Unknown functional impact |
| c.502G>A (p.Gly168Arg) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • acyltransferase activity (GO:0016746) |
| • lipid metabolic process (GO:0006629) | • lipid catabolic process (GO:0016042) |
| • plasma membrane (GO:0005886) |
Pathways
• Phospholipid remodeling (glycerophospholipid metabolism)
• Adipocyte differentiation
Protein Summary
PLAAT5 is a 152-amino acid protein with a single transmembrane domain. It localizes to the plasma membrane and endoplasmic reticulum. The protein catalyzes the hydrolysis of phospholipids at the sn-1 and sn-2 positions (phospholipase A1/A2) and also transfers acyl groups to lysophospholipids (acyltransferase). This dual activity is critical for membrane phospholipid homeostasis. Structural studies reveal a conserved catalytic triad (Ser-His-Asp) essential for enzymatic activity.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLAAT5 Knockout HEK293 Cell Line | EDJ-KQ7602 | Human | 117245 | Details Get a Quote |
| PLAAT5 Knockout HeLa Cell Line | EDJ-KQ58011 | Human | 117245 | Details Get a Quote |
| PLAAT5 Knockout A-549 Cell Line | EDJ-KQ66499 | Human | 117245 | Details Get a Quote |
| PLAAT5 Knockout HCT 116 Cell Line | EDJ-KQ74918 | Human | 117245 | Details Get a Quote |
