PLAAT1: Phospholipase A and Acyltransferase 1
A multifunctional enzyme involved in phospholipid metabolism and cellular signaling
Gene Information Card
| Symbol | PLAAT1 |
|---|---|
| Full Name | Phospholipase A and Acyltransferase 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 3q29 |
| NCBI Gene ID | 57126 ncbi.nlm.nih.gov/gene/57126 |
| Ensembl ID | ENSG00000163947 |
| UniProt ID | Q9BZM1 |
| OMIM ID | 611607 |
| HGNC ID | 14073 |
| Aliases | HRASLS2, H-REV107-1, PLA1A |
Description
PLAAT1 (Phospholipase A and Acyltransferase 1) is a protein-coding gene that encodes a bifunctional enzyme with both phospholipase A1/A2 and acyltransferase activities. The protein is involved in phospholipid metabolism, particularly in the remodeling of membrane phospholipids. PLAAT1 is also known as HRASLS2 due to its interaction with HRAS and its role in Ras signaling. It is expressed in various tissues and has been implicated in cancer and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various) | Altered expression may affect phospholipid remodeling and Ras signaling | COSMIC; NCBI Gene |
| Metabolic syndrome | Potential role in lipid metabolism dysregulation | UniProt; NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Adipose tissue | 8.2 | Low |
| Brain | 6.1 | Low |
| Liver | 4.3 | Low |
| Lung | 3.7 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression in kidney-derived cells |
| HeLa | 9.8 | Moderate expression in cervical cancer cells |
| HepG2 | 5.4 | Low expression in liver cancer cells |
| A549 | 4.1 | Low expression in lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287G>A (p.Arg96His) | Missense | <0.01% | Unknown; reported in COSMIC |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Unknown; reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase activity (GO:0004620) | • acyltransferase activity (GO:0008374) |
| • lipid metabolic process (GO:0006629) | • membrane (GO:0016020) |
| • cytoplasm (GO:0005737) |
Pathways
• Phospholipid remodeling (UniProt)
• Ras signaling (via HRAS interaction)
Protein Summary
PLAAT1 is a 230-amino acid protein with a molecular weight of approximately 26 kDa. It contains a conserved HxxxD motif characteristic of phospholipase A/acyltransferase enzymes. The protein localizes to the cytoplasm and membrane, where it catalyzes the hydrolysis and transfer of fatty acids from phospholipids. It interacts with HRAS and may modulate Ras signaling. Expression is highest in testis and adipose tissue.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLAAT1 Knockout HEK293 Cell Line | EDJ-KQ14779 | Human | 57110 | Details Get a Quote |
| PLAAT1 Knockout HeLa Cell Line | EDJ-KQ77965 | Human | 57110 | Details Get a Quote |
| PLAAT1 Knockout A-549 Cell Line | EDJ-KQ77966 | Human | 57110 | Details Get a Quote |
| PLAAT1 Knockout HCT 116 Cell Line | EDJ-KQ77967 | Human | 57110 | Details Get a Quote |
