PLA2G4F Gene - Phospholipase A2 Group IVF
Comprehensive genomic and functional analysis of PLA2G4F, a calcium-independent phospholipase A2 involved in lipid metabolism and signaling.
Gene Information Card
| Symbol | PLA2G4F |
|---|---|
| Full Name | Phospholipase A2 Group IVF |
| Gene Type | Protein coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 255189 ncbi.nlm.nih.gov/gene/255189 |
| Ensembl ID | ENSG00000168907 |
| UniProt ID | Q68DD2 |
| OMIM ID | 612401 |
| HGNC ID | 30002 |
| Aliases | cPLA2F, PLA2G4F, cytosolic phospholipase A2 zeta |
Description
PLA2G4F encodes a member of the cytosolic phospholipase A2 (cPLA2) family, which catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids. This enzyme is calcium-independent and preferentially hydrolyzes phosphatidylcholine. It plays a role in lipid mediator production, cell signaling, and membrane remodeling. The gene is located on chromosome 15q14 and is expressed in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered arachidonic acid metabolism may promote inflammation and tumorigenesis | COSMIC mutation data; elevated expression in tumor samples |
| Inflammatory disorders | Dysregulation of phospholipase activity can lead to excessive pro-inflammatory lipid mediator production | Inferred from pathway involvement; limited direct evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Small intestine | 8.3 | Low |
| Colon | 6.1 | Low |
| Prostate | 5.4 | Low |
| Lung | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HCT116 | 9.8 | Colorectal carcinoma cell line |
| A549 | 6.3 | Lung carcinoma cell line |
| HEK293 | 4.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1072G>A (p.Gly358Arg) | Missense | 0.02% (gnomAD) | Unknown functional effect |
| c.1543C>T (p.Arg515Trp) | Missense | 0.01% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • cytoplasm (GO:0005737) |
Pathways
• Arachidonic acid metabolism (Reactome: R-HSA-2142753)
• Phospholipid metabolism (Reactome: R-HSA-1483257)
Protein Summary
PLA2G4F is a 799-amino acid calcium-independent phospholipase A2 that localizes to the cytoplasm. It contains a C2 domain and a catalytic domain typical of cPLA2 enzymes. The protein preferentially hydrolyzes phosphatidylcholine at the sn-2 position, releasing arachidonic acid. It is involved in lipid signaling and membrane homeostasis. Expression is highest in testis and gastrointestinal tissues.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G4F Knockout HEK293 Cell Line | EDJ-KQ729 | Human | 255189 | Details Get a Quote |
| PLA2G4F Knockout HeLa Cell Line | EDJ-KQ59273 | Human | 255189 | Details Get a Quote |
| PLA2G4F Knockout A-549 Cell Line | EDJ-KQ67740 | Human | 255189 | Details Get a Quote |
| PLA2G4F Knockout HCT 116 Cell Line | EDJ-KQ76125 | Human | 255189 | Details Get a Quote |
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