PLA2G4E
Phospholipase A2 Group IVE
Gene Information Card
| Symbol | PLA2G4E |
|---|---|
| Full Name | Phospholipase A2 Group IVE |
| Gene Type | protein-coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 123745 ncbi.nlm.nih.gov/gene/123745 |
| Ensembl ID | ENSG00000188033 |
| UniProt ID | Q3MJ16 |
| OMIM ID | 612402 |
| HGNC ID | 30091 |
| Aliases | cPLA2epsilon, MGC131809 |
Description
PLA2G4E encodes a member of the cytosolic phospholipase A2 (cPLA2) family, specifically group IVE. This enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids, which are precursors for eicosanoid signaling. Unlike other cPLA2s, PLA2G4E is calcium-independent and exhibits lysophospholipase activity. It is implicated in lipid metabolism and inflammatory responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | N/A | No curated evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Brain | 1.8 | Low |
| Lung | 1.5 | Low |
| Heart | 1.2 | Low |
| Liver | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.5 | Moderate expression |
| HeLa | 1.8 | Low expression |
| K562 | 1.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported in ClinVar | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Gene Ontology (GO)
Pathways
• Arachidonic acid metabolism (Reactome: R-HSA-2142753)
• Glycerophospholipid biosynthesis (Reactome: R-HSA-1483206)
Protein Summary
PLA2G4E (cPLA2 epsilon) is a 541-amino acid protein with a molecular weight of approximately 61 kDa. It contains a C2 domain and a catalytic domain typical of group IV phospholipases, but lacks the calcium-binding residues, rendering it calcium-independent. The enzyme preferentially hydrolyzes phosphatidylcholine and phosphatidylethanolamine, contributing to membrane remodeling and lipid mediator production.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G4E Knockout HEK293 Cell Line | EDJ-KQ728 | Human | 123745 | Details Get a Quote |
| PLA2G4E Knockout HeLa Cell Line | EDJ-KQ58120 | Human | 123745 | Details Get a Quote |
| PLA2G4E Knockout A-549 Cell Line | EDJ-KQ66607 | Human | 123745 | Details Get a Quote |
| PLA2G4E Knockout HCT 116 Cell Line | EDJ-KQ75025 | Human | 123745 | Details Get a Quote |
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