PLA2G4C Gene - Phospholipase A2 Group IVC
Cytosolic phospholipase A2 gamma (cPLA2γ) - calcium-independent lipid mediator
Gene Information Card
| Symbol | PLA2G4C |
|---|---|
| Full Name | Phospholipase A2 Group IVC |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.33 |
| NCBI Gene ID | 8605 ncbi.nlm.nih.gov/gene/8605 |
| Ensembl ID | ENSG00000105499 |
| UniProt ID | Q9UP65 |
| OMIM ID | 603602 |
| HGNC ID | 9037 |
| Aliases | cPLA2gamma, cPLA2-gamma, GIVA cPLA2 |
Description
PLA2G4C encodes a member of the cytosolic phospholipase A2 (cPLA2) family, specifically group IVC. This enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids, precursors for eicosanoid signaling. Unlike other cPLA2 isoforms, PLA2G4C is calcium-independent and localizes to the endoplasmic reticulum and Golgi. It plays roles in lipid mediator production, membrane remodeling, and cellular signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered arachidonic acid metabolism may promote tumorigenesis | COSMIC mutation data; PMID: 23549398 |
| Inflammatory disorders | Dysregulated eicosanoid production contributes to chronic inflammation | UniProt annotation; PMID: 12080046 |
| Neuroblastoma | Overexpression linked to cell proliferation | PMID: 19160496 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Lung | 9.7 | Low |
| Skeletal muscle | 15.2 | Medium |
| Testis | 20.4 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 18.5 | High expression |
| HeLa | 12.3 | Medium expression |
| A549 | 9.8 | Low expression |
| K562 | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1132G>A (p.Gly378Arg) | missense | <0.01% | Unknown functional effect |
| c.1547C>T (p.Thr516Met) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • calcium-dependent phospholipid binding (GO:0005544) |
| • lipid catabolic process (GO:0016042) | • mitochondrion (GO:0005739) |
| • endoplasmic reticulum (GO:0005783) |
Pathways
• Arachidonic acid metabolism (Reactome R-HSA-2142753)
• Phospholipid metabolism (Reactome R-HSA-1483257)
• Eicosanoid signaling (KEGG hsa00590)
Protein Summary
PLA2G4C encodes cytosolic phospholipase A2 gamma (cPLA2γ), a 541-amino acid protein with a molecular weight of ~61 kDa. It contains a C2 domain and a catalytic domain typical of group IV phospholipases. Unlike PLA2G4A, it does not require calcium for membrane translocation. The enzyme preferentially hydrolyzes phospholipids with arachidonic acid at the sn-2 position, contributing to eicosanoid biosynthesis. It is widely expressed, with highest levels in testis and skeletal muscle.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G4C Knockout HEK293 Cell Line | EDJ-KQ727 | Human | 8605 | Details Get a Quote |
| PLA2G4C Knockout A-549 Cell Line | EDJ-KQ19353 | Human | 8605 | Details Get a Quote |
| PLA2G4C Knockout HeLa Cell Line | EDJ-KQ54950 | Human | 8605 | Details Get a Quote |
| PLA2G4C Knockout HCT 116 Cell Line | EDJ-KQ71902 | Human | 8605 | Details Get a Quote |
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