PLA2G4B Gene - Phospholipase A2 Group IVB
Cytosolic phospholipase A2 beta involved in lipid signaling and inflammation
Gene Information Card
| Symbol | PLA2G4B |
|---|---|
| Full Name | Phospholipase A2 Group IVB |
| Gene Type | Protein coding |
| Chromosomal Location | 15q14 |
| NCBI Gene ID | 100137049 ncbi.nlm.nih.gov/gene/100137049 |
| Ensembl ID | ENSG00000168906 |
| UniProt ID | P0C869 |
| OMIM ID | 612402 |
| HGNC ID | 30004 |
| Aliases | cPLA2-beta, cytosolic phospholipase A2 beta, PLA2G4B |
Description
PLA2G4B encodes cytosolic phospholipase A2 beta (cPLA2 beta), an enzyme that catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids. This reaction is a key step in the biosynthesis of eicosanoids, which are potent mediators of inflammation and cellular signaling. The protein is calcium-dependent and preferentially hydrolyzes phospholipids containing arachidonic acid at the sn-2 position. PLA2G4B is expressed in various tissues and is implicated in inflammatory responses and lipid metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory disorders | Altered arachidonic acid release and eicosanoid production | Inferred from functional studies; limited direct clinical evidence |
| Cancer | Dysregulated lipid signaling may promote tumor progression | COSMIC mutation data; expression changes in certain cancers |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 2.1 | Low |
| Lung | 1.5 | Low |
| Spleen | 1.8 | Low |
| Testis | 3.2 | Medium |
| Small intestine | 1.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.8 | Low expression |
| K-562 | 1.2 | Low expression |
| HeLa | 0.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T (p.Arg412Cys) | Missense | <0.01% | Unknown functional effect |
| c.567G>A (p.Trp189*) | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations (e.g., p.Trp189*) likely lead to truncated protein and loss of enzymatic activity.
Gain of Function (GOF)
No gain-of-function mutations reported in curated databases.
Dominant Negative (DN)
No dominant-negative mutations documented.
View complete mutation data：
Gene Ontology (GO)
| • GO:0004623 - phospholipase A2 activity | • GO:0005509 - calcium ion binding |
| • GO:0016042 - lipid catabolic process | • GO:0006644 - phospholipid metabolic process |
| • GO:0050482 - arachidonic acid secretion |
Pathways
• Arachidonic acid metabolism (Reactome: R-HSA-2142753)
• Phospholipid metabolism (Reactome: R-HSA-1483257)
Protein Summary
Cytosolic phospholipase A2 beta (cPLA2 beta) is a 1012-amino acid protein that contains a C2 domain for calcium-dependent membrane binding and a catalytic domain with lipase activity. It preferentially releases arachidonic acid from membrane phospholipids, providing substrate for cyclooxygenase and lipoxygenase pathways. The protein is expressed at low levels in most tissues, with highest expression in testis. Its role in eicosanoid synthesis positions it as a potential target for anti-inflammatory therapies.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| JMJD7-PLA2G4B Knockout HEK293 Cell Line | EDJ-KQ1267 | Human | 8681 | Details Get a Quote |
| PLA2G4B Knockout HEK293 Cell Line | EDJ-KQ1268 | Human | 100137049 | Details Get a Quote |
| JMJD7-PLA2G4B Knockout HCT 116 Cell Line | EDJ-KQ19292 | Human | 8681 | Details Get a Quote |
| JMJD7-PLA2G4B Knockout HeLa Cell Line | EDJ-KQ20644 | Human | 8681 | Details Get a Quote |
| PLA2G4B Knockout A-549 Cell Line | EDJ-KQ20645 | Human | 100137049 | Details Get a Quote |
| PLA2G4B Knockout HCT 116 Cell Line | EDJ-KQ20646 | Human | 100137049 | Details Get a Quote |
| PLA2G4B Knockout HeLa Cell Line | EDJ-KQ20647 | Human | 100137049 | Details Get a Quote |
| JMJD7-PLA2G4B Knockout A-549 Cell Line | EDJ-KQ63458 | Human | 8681 | Details Get a Quote |
| PLA2G4B Knockout HAP1 Cell Line | EDC08231 | Human | 100137049 | Details Get a Quote |
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