PLA2G3
Phospholipase A2 Group III
Gene Information Card
| Symbol | PLA2G3 |
|---|---|
| Full Name | Phospholipase A2 Group III |
| Gene Type | protein-coding |
| Chromosomal Location | 22q12.2 |
| NCBI Gene ID | 50487 ncbi.nlm.nih.gov/gene/50487 |
| Ensembl ID | ENSG00000100030 |
| UniProt ID | Q9NZ20 |
| OMIM ID | 611414 |
| HGNC ID | 9036 |
| Aliases | sPLA2-III, PLA2III, GIII-sPLA2 |
Description
PLA2G3 encodes a secreted phospholipase A2 (sPLA2) enzyme that catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid and lysophospholipids. This enzyme plays a role in lipid metabolism, inflammation, and cell signaling. It is expressed in various tissues and has been implicated in cancer, atherosclerosis, and allergic responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Overexpression promotes tumor growth via arachidonic acid metabolism | PMID: 23376921 |
| Asthma | Involvement in airway inflammation and eicosanoid production | PMID: 23911647 |
| Atherosclerosis | Modulation of lipid metabolism and inflammatory response | PMID: 25281747 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 0.8 | Low |
| Lung | 2.1 | Medium |
| Spleen | 1.5 | Low |
| Prostate | 3.2 | Medium |
| Testis | 4.5 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.2 | Low expression |
| A549 | 3.8 | Moderate expression |
| HCT116 | 5.1 | High expression |
| MCF7 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337C>T (p.Arg113Trp) | Missense | <0.01% | Unknown functional impact |
| c.458G>A (p.Arg153Gln) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • extracellular region (GO:0005576) |
| • plasma membrane (GO:0005886) |
Pathways
• Arachidonic acid metabolism (Reactome R-HSA-2142753)
• Phospholipid metabolism (Reactome R-HSA-1483257)
Protein Summary
PLA2G3 encodes a 55 kDa secreted phospholipase A2 enzyme (sPLA2-III) that preferentially hydrolyzes phosphatidylcholine and phosphatidylethanolamine. It contains a signal peptide and a conserved PLA2 domain. The enzyme is involved in eicosanoid biosynthesis and inflammatory signaling.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G3 Knockout HEK293 Cell Line | EDJ-KQ1259 | Human | 50487 | Details Get a Quote |
| PLA2G3 Knockout HeLa Cell Line | EDJ-KQ56164 | Human | 50487 | Details Get a Quote |
| PLA2G3 Knockout A-549 Cell Line | EDJ-KQ64653 | Human | 50487 | Details Get a Quote |
| PLA2G3 Knockout HCT 116 Cell Line | EDJ-KQ73102 | Human | 50487 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
