PLA2G2F Gene - Phospholipase A2 Group IIF
Comprehensive genomic and functional analysis of PLA2G2F, a secreted phospholipase A2 enzyme involved in lipid metabolism and inflammatory signaling.
Gene Information Card
| Symbol | PLA2G2F |
|---|---|
| Full Name | Phospholipase A2 Group IIF |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 64600 ncbi.nlm.nih.gov/gene/64600 |
| Ensembl ID | ENSG00000158793 |
| UniProt ID | Q9BZM2 |
| OMIM ID | 605630 |
| HGNC ID | 17856 |
| Aliases | sPLA2-IIF, PLA2G2F, GIIF sPLA2 |
Description
PLA2G2F encodes a member of the secreted phospholipase A2 (sPLA2) family, group IIF. This enzyme catalyzes the hydrolysis of the sn-2 ester bond of glycerophospholipids, releasing free fatty acids and lysophospholipids. It is involved in lipid metabolism, eicosanoid production, and inflammatory responses. Expression is predominantly in testis, skin, and certain epithelial tissues. The protein has been implicated in cancer progression and inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate Cancer | Overexpression of PLA2G2F promotes tumor growth and metastasis via arachidonic acid release and prostaglandin E2 synthesis. | PMID: 23431173 |
| Colorectal Cancer | Elevated PLA2G2F expression correlates with poor prognosis; contributes to inflammation-driven carcinogenesis. | PMID: 25670082 |
| Inflammatory Skin Disorders | PLA2G2F is upregulated in psoriatic skin lesions, contributing to local eicosanoid production and inflammation. | PMID: 20660018 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.3 | Medium |
| Skin | 8.7 | Medium |
| Prostate | 5.2 | Low |
| Colon | 3.1 | Low |
| Lung | 1.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 2.5 | Low expression |
| A549 | 1.2 | Not detected |
| MCF7 | 0.8 | Not detected |
| LNCaP | 6.4 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337G>A (p.Gly113Arg) | Missense | <0.01% | Unknown functional effect |
| c.421C>T (p.Arg141Trp) | Missense | <0.01% | Unknown functional effect |
| c.544_545insA | Frameshift | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift insertion c.544_545insA likely results in truncated protein and loss of catalytic activity.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • extracellular region (GO:0005576) |
| • plasma membrane (GO:0005886) |
Pathways
• Arachidonic acid metabolism (Reactome: R-HSA-2142753)
• Phospholipid metabolism (Reactome: R-HSA-1483206)
• Eicosanoid synthesis (Reactome: R-HSA-2142691)
Protein Summary
PLA2G2F is a 168-amino acid secreted phospholipase A2 enzyme with a conserved Ca2+-binding loop and catalytic His-Asp dyad. It preferentially hydrolyzes phosphatidylethanolamine and phosphatidylglycerol. The protein is expressed in testis, skin, and prostate, and is implicated in cancer and inflammatory diseases. Its structure includes a signal peptide (residues 1-20) and a mature chain (21-168).
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G2F Knockout HEK293 Cell Line | EDJ-KQ1260 | Human | 64600 | Details Get a Quote |
| PLA2G2F Knockout HeLa Cell Line | EDJ-KQ57066 | Human | 64600 | Details Get a Quote |
| PLA2G2F Knockout A-549 Cell Line | EDJ-KQ65578 | Human | 64600 | Details Get a Quote |
| PLA2G2F Knockout HCT 116 Cell Line | EDJ-KQ74008 | Human | 64600 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
