PLA2G2E Gene - Phospholipase A2 Group IIE
Comprehensive genomic and functional analysis of PLA2G2E, a secreted phospholipase involved in lipid metabolism and inflammatory signaling.
Gene Information Card
| Symbol | PLA2G2E |
|---|---|
| Full Name | Phospholipase A2 Group IIE |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 30814 ncbi.nlm.nih.gov/gene/30814 |
| Ensembl ID | ENSG00000188738 |
| UniProt ID | Q9NZK7 |
| OMIM ID | 605630 |
| HGNC ID | 9038 |
| Aliases | GIIE sPLA2, sPLA2-IIE, PLA2G2E |
Description
PLA2G2E encodes a member of the secreted phospholipase A2 (sPLA2) family, group IIE. This enzyme catalyzes the hydrolysis of the sn-2 position of glycerophospholipids to release free fatty acids and lysophospholipids, playing a role in lipid metabolism, eicosanoid production, and inflammatory responses. It is expressed in various tissues and has been implicated in immune regulation and metabolic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | PLA2G2E may contribute to airway inflammation via arachidonic acid release and eicosanoid synthesis. | PMID: 20037587 |
| Atherosclerosis | Enzyme activity in vascular tissues promotes lipid modification and inflammatory signaling. | PMID: 21518825 |
| Rheumatoid Arthritis | Elevated expression in synovial fluid correlates with joint inflammation. | PMID: 16914746 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 6.2 | Medium |
| Lung | 4.8 | Low |
| Spleen | 3.1 | Low |
| Liver | 1.5 | Not detected |
| Kidney | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 0.9 | Low expression |
| A549 | 2.1 | Moderate expression |
| THP-1 | 1.5 | Low expression |
| HepG2 | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337G>A (p.Gly113Arg) | Missense | <0.01% | Unknown functional effect |
| c.458C>T (p.Pro153Leu) | Missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Reactome: Release of arachidonic acid from phospholipids (R-HSA-1482788)
• KEGG: Arachidonic acid metabolism (hsa00590)
• KEGG: Inflammatory mediator regulation of TRP channels (hsa04750)
Protein Summary
PLA2G2E is a secreted phospholipase A2 enzyme of 145 amino acids (mature form) with a conserved calcium-binding domain and catalytic histidine-aspartate dyad. It preferentially hydrolyzes phosphatidylethanolamine and phosphatidylcholine, releasing arachidonic acid for eicosanoid biosynthesis. The protein is expressed in heart, lung, and spleen, and is implicated in inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G2E Knockout HEK293 Cell Line | EDJ-KQ1258 | Human | 30814 | Details Get a Quote |
| PLA2G2E Knockout HeLa Cell Line | EDJ-KQ56149 | Human | 30814 | Details Get a Quote |
| PLA2G2E Knockout A-549 Cell Line | EDJ-KQ64638 | Human | 30814 | Details Get a Quote |
| PLA2G2E Knockout HCT 116 Cell Line | EDJ-KQ73088 | Human | 30814 | Details Get a Quote |
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