PLA2G2D: Phospholipase A2 Group IID
Secreted phospholipase A2 involved in lipid metabolism and immune regulation
Gene Information Card
| Symbol | PLA2G2D |
|---|---|
| Full Name | Phospholipase A2 Group IID |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 26279 ncbi.nlm.nih.gov/gene/26279 |
| Ensembl ID | ENSG00000117228 |
| UniProt ID | Q9UNK4 |
| OMIM ID | 605630 |
| HGNC ID | 9036 |
| Aliases | sPLA2-IID, PLA2IID, SPLA2D, GVIA |
Description
PLA2G2D encodes a member of the secreted phospholipase A2 (sPLA2) family, group IID. This enzyme catalyzes the hydrolysis of the sn-2 acyl bond of phospholipids, releasing free fatty acids and lysophospholipids. It is involved in lipid metabolism, inflammatory responses, and host defense. The protein is expressed in various tissues, including immune cells, and has been implicated in cancer and autoimmune diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | Altered expression may influence tumor microenvironment via lipid mediator production | PMID: 25670082 |
| Rheumatoid Arthritis | Increased expression in synovial tissue; contributes to inflammation | PMID: 17913836 |
| Asthma | Polymorphisms associated with disease susceptibility | PMID: 19108745 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Small Intestine | 6.1 | Low |
| Colon | 5.4 | Low |
| Adipose Tissue | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | Differentiated macrophages show higher expression |
| A549 (lung epithelial) | 3.8 | Basal expression |
| HCT116 (colorectal) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.337G>A (p.Gly113Arg) | missense | <0.01% | Unknown functional effect |
| c.482C>T (p.Thr161Met) | missense | <0.01% | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • extracellular region (GO:0005576) |
| • plasma membrane (GO:0005886) |
Pathways
• Reactome: Phospholipid metabolism (R-HSA-1483206)
• Reactome: Arachidonic acid metabolism (R-HSA-2142753)
• KEGG: Glycerophospholipid metabolism (hsa00564)
Protein Summary
PLA2G2D encodes a 145-amino acid secreted phospholipase A2 (sPLA2-IID) with a conserved Ca2+-binding loop and catalytic His-Asp dyad. The protein is secreted and acts on extracellular phospholipids, generating lipid mediators such as arachidonic acid and lysophospholipids. It is expressed in immune tissues and modulates inflammatory and immune responses. Structural studies show a typical sPLA2 fold with three disulfide bonds.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G2D Knockout HEK293 Cell Line | EDJ-KQ1257 | Human | 26279 | Details Get a Quote |
| PLA2G2D Knockout HeLa Cell Line | EDJ-KQ55918 | Human | 26279 | Details Get a Quote |
| PLA2G2D Knockout A-549 Cell Line | EDJ-KQ64408 | Human | 26279 | Details Get a Quote |
| PLA2G2D Knockout HCT 116 Cell Line | EDJ-KQ72860 | Human | 26279 | Details Get a Quote |
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