PLA2G2C Gene - Phospholipase A2 Group IIC
Comprehensive genomic and functional analysis of PLA2G2C
Gene Information Card
| Symbol | PLA2G2C |
|---|---|
| Full Name | Phospholipase A2 Group IIC |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.12 |
| NCBI Gene ID | 7157 ncbi.nlm.nih.gov/gene/7157 |
| Ensembl ID | ENSG00000142675 |
| UniProt ID | P14555 |
| OMIM ID | 191170 |
| HGNC ID | 9032 |
| Aliases | PLA2G2C, sPLA2-IIC, G2C, PLA2IIC |
Description
PLA2G2C encodes a member of the secreted phospholipase A2 (sPLA2) family. This enzyme catalyzes the hydrolysis of the sn-2 position of glycerophospholipids to release arachidonic acid and lysophospholipids, which are precursors of eicosanoids and platelet-activating factor. The protein is involved in lipid metabolism, inflammation, and cell signaling.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory diseases | Altered arachidonic acid metabolism via sPLA2 activity | PMID: 12368274 |
| Cancer (e.g., colorectal) | Overexpression linked to tumor progression | PMID: 15601839 |
| Cardiovascular disease | Modulation of lipid mediators and atherosclerosis | PMID: 17213273 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 0.8 | Low |
| Small intestine | 0.5 | Low |
| Colon | 0.4 | Low |
| Prostate | 0.3 | Low |
| Lung | 0.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.1 | Low expression |
| HeLa | 0.05 | Very low |
| HepG2 | 0.03 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • cytoplasm (GO:0005737) |
Pathways
• Arachidonic acid metabolism (Reactome: R-HSA-2142753)
• Phospholipid metabolism (Reactome: R-HSA-1483257)
Protein Summary
PLA2G2C is a secreted phospholipase A2 enzyme (sPLA2-IIC) that hydrolyzes phospholipids to release arachidonic acid and lysophospholipids. It is involved in lipid signaling, inflammation, and cellular responses. Expression is low in most tissues, with highest levels in testis and gastrointestinal tract. Mutations are rare and not well characterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G2C Knockout HEK293 Cell Line | EDJ-KQ1266 | Human | 391013 | Details Get a Quote |
| PLA2G2C Knockout HeLa Cell Line | EDJ-KQ60203 | Human | 391013 | Details Get a Quote |
| PLA2G2C Knockout A-549 Cell Line | EDJ-KQ68665 | Human | 391013 | Details Get a Quote |
| PLA2G2C Knockout HCT 116 Cell Line | EDJ-KQ77032 | Human | 391013 | Details Get a Quote |
