PLA2G1B: Phospholipase A2 Group IB
Pancreatic Phospholipase A2 - Digestive Enzyme and Signaling Mediator
Gene Information Card
| Symbol | PLA2G1B |
|---|---|
| Full Name | Phospholipase A2 Group IB |
| Gene Type | protein-coding |
| Chromosomal Location | 12q24.31 |
| NCBI Gene ID | 5319 ncbi.nlm.nih.gov/gene/5319 |
| Ensembl ID | ENSG00000111011 |
| UniProt ID | P04054 |
| OMIM ID | 172410 |
| HGNC ID | 9030 |
| Aliases | PLA2, PLA2A, PPLA2, sPLA2-IB |
Description
PLA2G1B encodes a secreted phospholipase A2 enzyme primarily expressed in the pancreas. It catalyzes the hydrolysis of sn-2 fatty acyl bonds of phospholipids to release free fatty acids and lysophospholipids, playing a key role in dietary lipid digestion. The enzyme also participates in inflammatory signaling and has been implicated in pancreatic cancer and acute pancreatitis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Acute Pancreatitis | Excessive activation of PLA2G1B within pancreatic acinar cells leads to autodigestion and inflammation | PMID: 25921289 |
| Pancreatic Cancer | Overexpression of PLA2G1B promotes tumor cell proliferation and invasion via arachidonic acid metabolism | PMID: 29371790 |
| Crohn's Disease | Altered PLA2G1B expression may contribute to intestinal inflammation through dysregulated eicosanoid production | PMID: 21383956 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 1234.5 | High |
| Small Intestine | 45.2 | Medium |
| Stomach | 12.3 | Low |
| Colon | 5.6 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic cancer) | 156.7 | High expression |
| MIA PaCa-2 (pancreatic cancer) | 98.3 | Moderate expression |
| Caco-2 (colorectal) | 8.9 | Low expression |
| HepG2 (hepatocellular) | 1.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.331G>A (p.Gly111Arg) | Missense | <0.01% | Reduced enzymatic activity; associated with familial pancreatitis risk |
| c.422C>T (p.Thr141Met) | Missense | <0.01% | Altered substrate specificity; reported in pancreatic cancer |
| c.1A>G (p.Met1Val) | Start loss | <0.01% | Loss of protein expression; rare variant |
Mutation functional classification
Loss of Function (LOF)
Missense mutations (e.g., p.Gly111Arg) reduce catalytic activity, impairing lipid digestion and potentially increasing pancreatitis susceptibility.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in PLA2G1B.
Dominant Negative (DN)
No dominant-negative mutations described for PLA2G1B.
View complete mutation data：
Gene Ontology (GO)
| • phospholipase A2 activity (GO:0004623) | • lipid catabolic process (GO:0016042) |
| • phospholipid metabolic process (GO:0006644) | • extracellular region (GO:0005576) |
| • bone mineralization (GO:0030282) |
Pathways
• Phospholipid metabolism (Reactome: R-HSA-1483206)
• Arachidonic acid metabolism (KEGG: hsa00590)
• Pancreatic secretion (KEGG: hsa04972)
Protein Summary
PLA2G1B is a 144-amino acid secreted protein (mature form: 125 residues) with a molecular weight of approximately 14 kDa. It contains a conserved Ca2+-binding loop and a catalytic His-Asp dyad. The enzyme is synthesized as a zymogen and activated by tryptic cleavage. It preferentially hydrolyzes phosphatidylcholine and phosphatidylethanolamine at the sn-2 position, releasing arachidonic acid and lysophospholipids. The protein is a member of the secreted phospholipase A2 family (sPLA2) and is abundant in pancreatic juice.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PLA2G1B Knockout HEK293 Cell Line | EDJ-KQ1263 | Human | 5319 | Details Get a Quote |
| PLA2G1B Knockout HeLa Cell Line | EDJ-KQ54149 | Human | 5319 | Details Get a Quote |
| PLA2G1B Knockout A-549 Cell Line | EDJ-KQ62642 | Human | 5319 | Details Get a Quote |
| PLA2G1B Knockout HCT 116 Cell Line | EDJ-KQ71110 | Human | 5319 | Details Get a Quote |
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