PKIG Gene - cAMP-Dependent Protein Kinase Inhibitor Gamma
A comprehensive biomedical resource on PKIG: genomic data, expression, mutations, and clinical relevance.
Gene Information Card
| Symbol | PKIG |
|---|---|
| Full Name | cAMP-dependent protein kinase inhibitor gamma |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 11142 ncbi.nlm.nih.gov/gene/11142 |
| Ensembl ID | ENSG00000101210 |
| UniProt ID | Q9Y2B0 |
| OMIM ID | 604932 |
| HGNC ID | 9020 |
| Aliases | PKI-gamma, PRKACG, PKI3 |
Description
PKIG encodes the gamma isoform of the cAMP-dependent protein kinase inhibitor (PKI). This protein binds to the catalytic subunit of PKA (protein kinase A) and inhibits its activity, playing a role in regulating cAMP-mediated signaling pathways. PKIG is involved in cellular processes such as differentiation, proliferation, and metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association reported in ClinVar or OMIM | Not established | No direct evidence from authoritative sources |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 12.5 | Medium |
| Brain | 8.2 | Low |
| Heart | 6.1 | Low |
| Liver | 3.4 | Low |
| Kidney | 5.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | Moderate expression |
| HeLa | 10.1 | Low expression |
| K562 | 7.8 | Low expression |
| A549 | 6.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; effect unknown |
| c.100C>T (p.Arg34Trp) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • cAMP-dependent protein kinase inhibitor activity (GO:0004862) | • protein binding (GO:0005515) |
| • cytoplasm (GO:0005737) | • nucleus (GO:0005634) |
Pathways
• cAMP/PKA signaling pathway (Reactome: R-HSA-163615)
Protein Summary
PKIG is a 76-amino acid protein that functions as a specific inhibitor of the catalytic subunit of cAMP-dependent protein kinase (PKA). It contains a pseudosubstrate sequence that binds to the active site of PKA, preventing substrate phosphorylation. PKIG is predominantly expressed in testis and brain, and its expression is regulated during development and in response to hormonal signals.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PKIG Knockout HEK293 Cell Line | EDJ-KQ7300 | Human | 11142 | Details Get a Quote |
| PKIG Knockout HeLa Cell Line | EDJ-KQ30972 | Human | 11142 | Details Get a Quote |
| PKIG Knockout A-549 Cell Line | EDJ-KQ32346 | Human | 11142 | Details Get a Quote |
| PKIG Knockout HCT 116 Cell Line | EDJ-KQ32347 | Human | 11142 | Details Get a Quote |
