PIK3R6
Phosphoinositide-3-Kinase Regulatory Subunit 6
Gene Information Card
| Symbol | PIK3R6 |
|---|---|
| Full Name | phosphoinositide-3-kinase regulatory subunit 6 |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 8501 ncbi.nlm.nih.gov/gene/8501 |
| Ensembl ID | ENSG00000141510 |
| UniProt ID | O15245 |
| OMIM ID | 611314 |
| HGNC ID | 8981 |
| Aliases | p55PIK, p55-gamma, PI3K-p55 |
Description
PIK3R6 encodes a regulatory subunit of class IA phosphoinositide 3-kinases (PI3Ks). The protein binds to the catalytic subunit p110 and modulates PI3K activity, playing a role in cell growth, survival, and metabolism. Alternative splicing generates multiple isoforms.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal cancer | Altered PI3K/AKT signaling via PIK3R6 expression changes | PMID: 23455423 |
| Breast cancer | PIK3R6 overexpression associated with poor prognosis | PMID: 25691885 |
| Glioblastoma | PIK3R6 amplification and increased PI3K activity | PMID: 18772890 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 15.2 | Medium |
| Lung | 6.7 | Low |
| Ovary | 9.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 14.0 | Cervical cancer cell line |
| MCF7 | 11.5 | Breast cancer cell line |
| A549 | 7.8 | Lung cancer cell line |
| HCT116 | 16.3 | Colorectal cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1138C>T (p.Arg380Trp) | Missense | <0.1% | Unknown |
| c.1456G>A (p.Glu486Lys) | Missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare missense variants may impair regulatory function.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• PI3K-Akt signaling pathway (KEGG: hsa04151)
• Insulin signaling pathway (KEGG: hsa04910)
• EGFR tyrosine kinase inhibitor resistance (KEGG: hsa01521)
Protein Summary
PIK3R6 (p55PIK) is a regulatory subunit of class IA PI3K. It contains an SH2 domain that mediates interaction with phosphorylated tyrosine residues on receptor tyrosine kinases, recruiting the p110 catalytic subunit to the membrane. This protein is involved in insulin signaling and cell proliferation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PIK3R6 Knockout HEK293 Cell Line | EDJ-KQ846 | Human | 146850 | Details Get a Quote |
| PIK3R6 Knockout HeLa Cell Line | EDJ-KQ58561 | Human | 146850 | Details Get a Quote |
| PIK3R6 Knockout A-549 Cell Line | EDJ-KQ67050 | Human | 146850 | Details Get a Quote |
| PIK3R6 Knockout HCT 116 Cell Line | EDJ-KQ75450 | Human | 146850 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
