PI15
Peptidase Inhibitor 15
Gene Information Card
| Symbol | PI15 |
|---|---|
| Full Name | Peptidase Inhibitor 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 8q21.13 |
| NCBI Gene ID | 51050 ncbi.nlm.nih.gov/gene/51050 |
| Ensembl ID | ENSG00000137558 |
| UniProt ID | Q8WXI7 |
| OMIM ID | 607076 |
| HGNC ID | 17996 |
| Aliases | P25, P15, PPI15 |
Description
PI15 (Peptidase Inhibitor 15) encodes a protein that belongs to the serpin family of serine protease inhibitors. It is involved in the regulation of proteolytic cascades and may play a role in tissue remodeling, inflammation, and cancer. The gene is located on chromosome 8q21.13 and is expressed in various tissues, with highest levels in the pancreas and salivary glands.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | Altered expression may contribute to tumor progression via protease inhibition imbalance | PMID: 25944712 |
| Ovarian cancer | Upregulation associated with poor prognosis and metastasis | PMID: 27107036 |
| Type 2 diabetes | Potential involvement in insulin resistance through modulation of protease activity | PMID: 28424221 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 56.3 | High |
| Salivary gland | 42.1 | High |
| Liver | 18.7 | Medium |
| Kidney | 12.4 | Medium |
| Lung | 5.2 | Low |
| Brain | 2.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| PANC-1 (pancreatic) | 45.8 | High expression |
| HepG2 (liver) | 22.3 | Moderate expression |
| A549 (lung) | 6.7 | Low expression |
| MCF7 (breast) | 3.4 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.374C>T (p.Thr125Met) | missense | 0.0002 | Unknown functional effect |
| c.1015G>A (p.Gly339Arg) | missense | 0.0001 | Reported in COSMIC as somatic in pancreatic cancer |
| c.1228_1230del (p.Lys410del) | in-frame deletion | 0.00005 | Loss of inhibitory activity predicted |
Mutation functional classification
Loss of Function (LOF)
In-frame deletion (p.Lys410del) predicted to disrupt serpin reactive center loop, reducing protease inhibition.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • serine-type endopeptidase inhibitor activity (GO:0004867) | • extracellular region (GO:0005576) |
| • negative regulation of endopeptidase activity (GO:0010951) |
Pathways
• Serine protease inhibitor pathway (Reactome: R-HSA-1474228)
• Regulation of insulin-like growth factor (IGF) transport and uptake (Reactome: R-HSA-381426)
Protein Summary
The PI15 protein (UniProt Q8WXI7) is a 45 kDa secreted serpin that inhibits trypsin-like serine proteases. It contains a conserved serpin domain with a reactive center loop (RCL) that acts as a bait for target proteases. The protein is glycosylated and localized to the extracellular matrix, where it modulates proteolytic activity during tissue remodeling and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PI15 Knockout HEK293 Cell Line | EDJ-KQ10888 | Human | 51050 | Details Get a Quote |
| PI15 Knockout HCT 116 Cell Line | EDJ-KQ38585 | Human | 51050 | Details Get a Quote |
| PI15 Knockout HeLa Cell Line | EDJ-KQ56219 | Human | 51050 | Details Get a Quote |
| PI15 Knockout A-549 Cell Line | EDJ-KQ64710 | Human | 51050 | Details Get a Quote |
