PGRMC1 (Progesterone Receptor Membrane Component 1)
A multifunctional heme-binding protein involved in steroid signaling, cancer, and neuroprotection.
Gene Information Card
| Symbol | PGRMC1 |
|---|---|
| Full Name | Progesterone Receptor Membrane Component 1 |
| Gene Type | Protein coding |
| Chromosomal Location | Xq24 |
| NCBI Gene ID | 10857 ncbi.nlm.nih.gov/gene/10857 |
| Ensembl ID | ENSG00000101856 |
| UniProt ID | O00264 |
| OMIM ID | 300435 |
| HGNC ID | 8909 |
| Aliases | HPR6.6, IZA, DKFZp564A043, mPR |
Description
PGRMC1 encodes a membrane-associated progesterone receptor that binds heme and mediates rapid, non-genomic progesterone signaling. It is involved in cell survival, proliferation, migration, and steroid hormone metabolism. The protein is highly conserved and expressed in multiple tissues, with roles in cancer progression, neuroprotection, and female reproductive physiology.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | PGRMC1 overexpression promotes proliferation and anti-apoptotic signaling via PI3K/AKT and MAPK pathways. | ClinVar, COSMIC, NCBI |
| Ovarian cancer | Increased PGRMC1 expression correlates with chemoresistance and poor prognosis. | COSMIC, NCBI |
| Endometrial cancer | PGRMC1 enhances cell migration and invasion through heme-dependent mechanisms. | COSMIC, NCBI |
| Neurodegenerative disorders | PGRMC1 exerts neuroprotective effects by reducing oxidative stress and apoptosis. | NCBI, OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Breast | 12.5 | Medium |
| Ovary | 8.3 | Low |
| Endometrium | 15.2 | Medium |
| Brain | 6.1 | Low |
| Liver | 4.8 | Low |
| Kidney | 7.9 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF-7 (breast cancer) | 18.4 | High expression |
| SK-OV-3 (ovarian cancer) | 9.7 | Medium expression |
| HepG2 (liver cancer) | 5.2 | Low expression |
| SH-SY5Y (neuroblastoma) | 7.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.1% | Likely loss of start codon; functional impact unknown |
| c.376C>T (p.Arg126Cys) | Missense | <0.1% | May alter heme binding; uncertain significance |
| c.482G>A (p.Arg161Gln) | Missense | <0.1% | Reported in COSMIC; functional effect not established |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • progesterone receptor activity | • heme binding |
| • protein homodimerization activity | • membrane |
| • cytoplasm | • endoplasmic reticulum |
| • signal transduction | • cell proliferation |
| • apoptotic process |
Pathways
• Progesterone-mediated oocyte maturation
• PI3K-Akt signaling pathway
• MAPK signaling pathway
Protein Summary
PGRMC1 is a 25 kDa transmembrane protein with a single heme-binding domain. It localizes to the endoplasmic reticulum and plasma membrane, where it interacts with multiple partners including EGFR, PAIRBP1, and SERBP1. The protein mediates rapid progesterone effects, regulates cytochrome P450 activity, and modulates cell survival pathways. Its expression is upregulated in several cancers and linked to therapy resistance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGRMC1 Knockout HEK293 Cell Line | EDJ-KQ7190 | Human | 10857 | Details Get a Quote |
| PGRMC1 Knockout A-549 Cell Line | EDJ-KQ32130 | Human | 10857 | Details Get a Quote |
| PGRMC1 Knockout HCT 116 Cell Line | EDJ-KQ32131 | Human | 10857 | Details Get a Quote |
| PGRMC1 Knockout HeLa Cell Line | EDJ-KQ32132 | Human | 10857 | Details Get a Quote |
