PGP
Phosphoglycolate Phosphatase
Gene Information Card
| Symbol | PGP |
|---|---|
| Full Name | Phosphoglycolate Phosphatase |
| Gene Type | Protein coding |
| Chromosomal Location | 16p13.3 |
| NCBI Gene ID | 283871 ncbi.nlm.nih.gov/gene/283871 |
| Ensembl ID | ENSG00000167193 |
| UniProt ID | A6NDG6 |
| OMIM ID | 616227 |
| HGNC ID | 30090 |
| Aliases | GPG, MGC16121, dJ1009E9.1 |
Description
The PGP gene encodes phosphoglycolate phosphatase, an enzyme that catalyzes the dephosphorylation of 2-phosphoglycolate to glycolate and inorganic phosphate. This reaction is part of the 2-phosphoglycolate salvage pathway, which detoxifies 2-phosphoglycolate produced as a byproduct of DNA repair and other metabolic processes. The enzyme is also involved in the regulation of intracellular phosphate levels and has been implicated in cancer cell metabolism.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered PGP expression may affect cellular phosphate metabolism and promote tumor growth | COSMIC; literature |
| 2-Phosphoglycolate accumulation disorders | Deficiency in PGP leads to accumulation of 2-phosphoglycolate, potentially causing cellular toxicity | OMIM; literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Kidney | 10.2 | Medium |
| Heart | 8.9 | Medium |
| Brain | 6.3 | Low |
| Lung | 7.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 15.3 | High expression |
| HeLa | 11.8 | Medium expression |
| MCF7 | 9.4 | Medium expression |
| A549 | 8.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown |
| c.100C>T | Nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • phosphoglycolate phosphatase activity | • magnesium ion binding |
| • dephosphorylation | • glycolate metabolic process |
| • cellular phosphate ion homeostasis |
Pathways
• 2-phosphoglycolate salvage pathway
• Glycolate metabolism
Protein Summary
Phosphoglycolate phosphatase (PGP) is a 32 kDa enzyme that belongs to the haloacid dehalogenase (HAD) superfamily. It specifically hydrolyzes 2-phosphoglycolate to glycolate and phosphate. The protein is localized in the cytoplasm and is expressed in multiple tissues, with highest levels in liver and kidney. PGP plays a critical role in detoxifying 2-phosphoglycolate, which can inhibit glycolysis and DNA repair if accumulated.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGPEP1L Knockout HEK293 Cell Line | EDJ-KQ10456 | Human | 145814 | Details Get a Quote |
| PGPEP1 Knockout HEK293 Cell Line | EDJ-KQ11955 | Human | 54858 | Details Get a Quote |
| PGP Knockout HEK293 Cell Line | EDJ-KQ12015 | Human | 283871 | Details Get a Quote |
| PGP Knockout HCT 116 Cell Line | EDJ-KQ39359 | Human | 283871 | Details Get a Quote |
| PGPEP1 Knockout A-549 Cell Line | EDJ-KQ40485 | Human | 54858 | Details Get a Quote |
| PGPEP1 Knockout HCT 116 Cell Line | EDJ-KQ40486 | Human | 54858 | Details Get a Quote |
| PGPEP1 Knockout HeLa Cell Line | EDJ-KQ40487 | Human | 54858 | Details Get a Quote |
| PGP Knockout A-549 Cell Line | EDJ-KQ40611 | Human | 283871 | Details Get a Quote |
| PGP Knockout HeLa Cell Line | EDJ-KQ40612 | Human | 283871 | Details Get a Quote |
| PGPEP1L Knockout HeLa Cell Line | EDJ-KQ58528 | Human | 145814 | Details Get a Quote |
| PGPEP1L Knockout A-549 Cell Line | EDJ-KQ67019 | Human | 145814 | Details Get a Quote |
| PGPEP1L Knockout HCT 116 Cell Line | EDJ-KQ75419 | Human | 145814 | Details Get a Quote |
