PGCKA1
Phosphoglycerate Cytidylyltransferase 1
Gene Information Card
| Symbol | PGCKA1 |
|---|---|
| Full Name | Phosphoglycerate Cytidylyltransferase 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p36.13 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000204103 |
| UniProt ID | Q5T6F2 |
| OMIM ID | 618123 |
| HGNC ID | 44167 |
| Aliases | MGC16121, dJ402H5.2 |
Description
PGCKA1 encodes a cytidylyltransferase that catalyzes the conversion of 3-phospho-D-glycerate to CDP-3-phospho-D-glycerate, involved in the biosynthesis of teichoic acids in bacteria; its function in humans is not fully characterized.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No known disease association | Not established | No evidence |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 2.1 | Low |
| Liver | 1.0 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 3.8 | Low expression |
| K562 | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Not reported
Gain of Function (GOF)
Not reported
Dominant Negative (DN)
Not reported
View complete mutation data：
Gene Ontology (GO)
| • nucleotidyltransferase activity | • cytidylyltransferase activity |
| • CDP-3-phospho-D-glycerate biosynthetic process |
Pathways
• Teichoic acid biosynthesis (bacterial)
Protein Summary
PGCKA1 is a 229-amino acid protein with a predicted molecular weight of 26 kDa, containing a cytidylyltransferase domain; its role in human cells remains unclear.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGCKA1 Knockout HEK293 Cell Line | EDJ-KQ51443 | Human | 55286 | Details Get a Quote |
| PGCKA1 Knockout HeLa Cell Line | EDJ-KQ56571 | Human | 55286 | Details Get a Quote |
| PGCKA1 Knockout A-549 Cell Line | EDJ-KQ65068 | Human | 55286 | Details Get a Quote |
| PGCKA1 Knockout HCT 116 Cell Line | EDJ-KQ73513 | Human | 55286 | Details Get a Quote |
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