PGC
Progastricsin (Pepsinogen C) – A Key Gastric Aspartic Protease
Gene Information Card
| Symbol | PGC |
|---|---|
| Full Name | Progastricsin (pepsinogen C) |
| Gene Type | Protein coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 5225 ncbi.nlm.nih.gov/gene/5225 |
| Ensembl ID | ENSG00000112210 |
| UniProt ID | P20142 |
| OMIM ID | 169740 |
| HGNC ID | 8890 |
| Aliases | PEPC, pepsinogen C, gastricsin |
Description
The PGC gene encodes progastricsin, also known as pepsinogen C, a precursor of the gastric aspartic protease gastricsin. This enzyme is secreted by gastric chief cells and is involved in protein digestion in the stomach. PGC expression is often downregulated in gastric cancer and other gastric disorders, making it a potential biomarker for gastric mucosal integrity and differentiation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric Cancer | Loss of PGC expression is associated with gastric carcinogenesis; reduced progastricsin levels reflect loss of chief cell differentiation. | Multiple studies; NCBI Gene, PubMed |
| Atrophic Gastritis | Decreased PGC expression correlates with gastric atrophy and intestinal metaplasia. | ClinVar, literature |
| Peptic Ulcer Disease | Altered pepsinogen levels (including PGC) are observed in patients with peptic ulcers. | OMIM, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 1024.3 | High |
| Esophagus | 12.1 | Low |
| Duodenum | 8.5 | Low |
| Pancreas | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MKN45 (gastric cancer) | 450.2 | Moderate expression |
| KATO III (gastric cancer) | 320.8 | Moderate expression |
| HEK 293 (embryonic kidney) | 0.5 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.67C>T (p.Arg23Cys) | Missense | Rare | Unknown functional impact |
| c.245G>A (p.Arg82His) | Missense | Rare | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in PGC.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • aspartic-type endopeptidase activity (GO:0004190) | • proteolysis (GO:0006508) |
| • extracellular region (GO:0005576) | • extracellular exosome (GO:0070062) |
Pathways
• Digestion and absorption of proteins (Reactome: R-HSA-8963748)
• Pepsinogen activation (Reactome: R-HSA-8963748)
Protein Summary
Progastricsin (PGC) is a 388-amino-acid precursor protein that is proteolytically cleaved to yield active gastricsin, an aspartic protease. It is primarily expressed in gastric chief cells and secreted into the stomach lumen. The enzyme functions optimally at acidic pH and contributes to the digestion of dietary proteins. Reduced expression is a hallmark of gastric atrophy and gastric cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGC Knockout HEK293 Cell Line | EDJ-KQ5450 | Human | 5225 | Details Get a Quote |
| PGCKA1 Knockout HEK293 Cell Line | EDJ-KQ51443 | Human | 55286 | Details Get a Quote |
| PGC Knockout HeLa Cell Line | EDJ-KQ54127 | Human | 5225 | Details Get a Quote |
| PGCKA1 Knockout HeLa Cell Line | EDJ-KQ56571 | Human | 55286 | Details Get a Quote |
| PGC Knockout A-549 Cell Line | EDJ-KQ62617 | Human | 5225 | Details Get a Quote |
| PGCKA1 Knockout A-549 Cell Line | EDJ-KQ65068 | Human | 55286 | Details Get a Quote |
| PGC Knockout HCT 116 Cell Line | EDJ-KQ71089 | Human | 5225 | Details Get a Quote |
| PGCKA1 Knockout HCT 116 Cell Line | EDJ-KQ73513 | Human | 55286 | Details Get a Quote |
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