PGA4 Gene - Pepsinogen A4
PGA4: A gastric aspartic protease precursor involved in protein digestion and gastric physiology.
Gene Information Card
| Symbol | PGA4 |
|---|---|
| Full Name | Pepsinogen A4 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 643847 ncbi.nlm.nih.gov/gene/643847 |
| Ensembl ID | ENSG00000196262 |
| UniProt ID | P00790 |
| OMIM ID | 169710 |
| HGNC ID | 8890 |
| Aliases | PGA, pepsinogen A, pepsinogen-4 |
Description
PGA4 encodes pepsinogen A4, a precursor of the gastric enzyme pepsin A. Pepsin A is an aspartic protease that is activated in the acidic environment of the stomach and plays a key role in protein digestion. The gene is part of a cluster of pepsinogen genes on chromosome 11. Expression is primarily in the gastric mucosa.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric cancer | Altered pepsinogen levels are associated with gastric atrophy and increased cancer risk; PGA4 expression may be dysregulated. | NCBI Gene, OMIM |
| Peptic ulcer disease | Changes in pepsinogen secretion can contribute to mucosal damage. | NCBI Gene |
| Gastritis | Inflammation of gastric mucosa affects pepsinogen production. | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 127.3 | High |
| Esophagus | 1.2 | Low |
| Duodenum | 0.8 | Low |
| Pancreas | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MKN7 (gastric cancer) | 45.2 | Moderate expression |
| KATO III (gastric cancer) | 12.8 | Low expression |
| HEK 293 | 0.0 | Not expressed |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown effect |
| c.67C>T | missense | <0.01% | Unknown effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • aspartic-type endopeptidase activity | • proteolysis |
| • pepsinogen activation | • extracellular space |
Pathways
• Digestion and absorption of proteins
• Gastric acid secretion
Protein Summary
Pepsinogen A4 is a 388-amino-acid precursor protein that is cleaved to form active pepsin A. The active enzyme is an aspartic protease with optimal activity at low pH. It is secreted by chief cells in the stomach and initiates protein digestion. The protein contains a signal peptide and an activation peptide that is removed upon acidification.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGA4 Knockout HEK293 Cell Line | EDJ-KQ5448 | Human | 643847 | Details Get a Quote |
| PGA4 Knockout HeLa Cell Line | EDJ-KQ60554 | Human | 643847 | Details Get a Quote |
| PGA4 Knockout A-549 Cell Line | EDJ-KQ69025 | Human | 643847 | Details Get a Quote |
| PGA4 Knockout HCT 116 Cell Line | EDJ-KQ77382 | Human | 643847 | Details Get a Quote |
