PGA3 Gene - Pepsinogen A3
Comprehensive genomic and proteomic analysis of PGA3, a key gastric aspartic protease precursor.
Gene Information Card
| Symbol | PGA3 |
|---|---|
| Full Name | Pepsinogen A3 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q12.2 |
| NCBI Gene ID | 643834 ncbi.nlm.nih.gov/gene/643834 |
| Ensembl ID | ENSG00000196262 |
| UniProt ID | P00790 |
| OMIM ID | 169710 |
| HGNC ID | 8891 |
| Aliases | PGA, pepsinogen A, pepsinogen A3 |
Description
PGA3 (Pepsinogen A3) is a protein-coding gene located on chromosome 11q12.2. It encodes a precursor of pepsin A, an aspartic protease secreted by gastric chief cells. Pepsinogen A3 is activated to pepsin A in the acidic gastric environment and plays a key role in protein digestion. The gene is part of the pepsinogen A gene cluster and is frequently used as a biomarker for gastric mucosal status and gastric cancer risk.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Gastric Cancer | Altered expression of PGA3 is associated with gastric carcinogenesis; reduced pepsinogen levels are used as a serological marker for atrophic gastritis and gastric cancer risk. | ClinVar, COSMIC |
| Atrophic Gastritis | Decreased PGA3 expression reflects loss of gastric chief cells in chronic atrophic gastritis. | ClinVar, NCBI |
| Peptic Ulcer Disease | Pepsinogen levels, including PGA3, are altered in peptic ulcer disease, though direct causal mechanisms are not fully established. | NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Stomach | 127.6 | High |
| Esophagus | 1.2 | Low |
| Duodenum | 0.8 | Low |
| Pancreas | 0.3 | Not detected |
| Liver | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MKN7 (gastric cancer) | 45.2 | Moderate expression |
| KATO III (gastric cancer) | 32.1 | Moderate expression |
| AGS (gastric adenocarcinoma) | 28.5 | Moderate expression |
| HEK 293 (embryonic kidney) | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Missense; potential effect on start codon |
| c.67C>T | SNV | <0.01% | Missense; p.Arg23Cys |
| c.124G>A | SNV | <0.01% | Missense; p.Gly42Ser |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC for PGA3.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • aspartic-type endopeptidase activity | • proteolysis |
| • extracellular region | • pepsinogen activation |
| • protein digestion |
Pathways
• Gastric acid secretion
• Digestion and absorption of proteins
Protein Summary
Pepsinogen A3 is a 388-amino-acid precursor protein (UniProt P00790) that is cleaved in the acidic gastric lumen to form active pepsin A. The active enzyme is an aspartic protease with broad specificity for hydrophobic residues. It is primarily expressed in gastric chief cells and secreted into the stomach lumen. The protein structure includes a signal peptide (residues 1-16) and an activation peptide (residues 17-58) that is removed during activation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PGA3 Knockout HEK293 Cell Line | EDJ-KQ5447 | Human | 643834 | Details Get a Quote |
| PGA3 Knockout HeLa Cell Line | EDJ-KQ60553 | Human | 643834 | Details Get a Quote |
| PGA3 Knockout A-549 Cell Line | EDJ-KQ69024 | Human | 643834 | Details Get a Quote |
| PGA3 Knockout HCT 116 Cell Line | EDJ-KQ77381 | Human | 643834 | Details Get a Quote |
