PEPC Gene (Phosphoenolpyruvate Carboxylase)
Comprehensive genomic and functional analysis of the PEPC gene, encoding phosphoenolpyruvate carboxylase, a key enzyme in carbon fixation and metabolic regulation.
Gene Information Card
| Symbol | PEPC |
|---|---|
| Full Name | Phosphoenolpyruvate carboxylase |
| Gene Type | protein-coding |
| Chromosomal Location | Not assigned to a specific human chromosome; PEPC is primarily studied in plants and bacteria. In humans, no ortholog has been identified. |
| NCBI Gene ID | 0 ncbi.nlm.nih.gov/gene/0 |
| Ensembl ID | Not available for human. |
| UniProt ID | Not available for human. |
| OMIM ID | Not available for human. |
| HGNC ID | Not available for human. |
| Aliases | PEP carboxylase, PEPC, phosphoenolpyruvate carboxylase |
Description
PEPC (phosphoenolpyruvate carboxylase) is an enzyme that catalyzes the irreversible carboxylation of phosphoenolpyruvate (PEP) to oxaloacetate, a key step in carbon fixation and the tricarboxylic acid (TCA) cycle. In plants, PEPC is critical for C4 and CAM photosynthesis, while in bacteria it is involved in anaplerotic reactions. No human ortholog has been identified; the gene is primarily studied in plants (e.g., Arabidopsis thaliana) and bacteria (e.g., Escherichia coli).
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|
Mutation functional classification
Loss of Function (LOF)
Gain of Function (GOF)
Dominant Negative (DN)
View complete mutation data：
Protein Summary
Phosphoenolpyruvate carboxylase (PEPC) is a homotetrameric enzyme that catalyzes the conversion of phosphoenolpyruvate and bicarbonate to oxaloacetate and inorganic phosphate. It is allosterically regulated by metabolites such as malate and glucose-6-phosphate. PEPC plays a central role in carbon metabolism, particularly in C4 and CAM plants, and in bacterial anaplerosis. No human protein has been characterized.
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| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
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