PEAK3
Pseudopodium-Enriched Atypical Kinase 3
Gene Information Card
| Symbol | PEAK3 |
|---|---|
| Full Name | Pseudopodium-Enriched Atypical Kinase 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.2 |
| NCBI Gene ID | 374977 ncbi.nlm.nih.gov/gene/374977 |
| Ensembl ID | ENSG00000188215 |
| UniProt ID | Q6ZNE5 |
| OMIM ID | 618988 |
| HGNC ID | 33895 |
| Aliases | FLJ45252, MGC16384 |
Description
PEAK3 (Pseudopodium-Enriched Atypical Kinase 3) is a protein-coding gene that encodes a member of the PEAK family of pseudokinases. The protein localizes to pseudopodia and regulates cell migration, cytoskeletal dynamics, and signaling pathways. PEAK3 is implicated in cancer cell invasion and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Overexpression promotes cell migration and invasion via cytoskeletal remodeling | PMID: 31073040 |
| Colorectal cancer | Upregulation correlates with poor prognosis and metastatic potential | PMID: 32015548 |
| Lung adenocarcinoma | PEAK3 amplification associated with tumor progression | PMID: 33093467 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Breast | 8.1 | Medium |
| Colon | 6.7 | Medium |
| Lung | 7.4 | Medium |
| Ovary | 4.9 | Low |
| Testis | 12.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 9.5 | Moderate expression |
| HCT116 (colorectal cancer) | 11.2 | High expression |
| A549 (lung cancer) | 8.8 | Moderate expression |
| HEK293 (embryonic kidney) | 6.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1015C>T (p.Arg339Trp) | Missense | <0.1% (COSMIC) | Unknown functional effect |
| c.1423G>A (p.Glu475Lys) | Missense | <0.1% (COSMIC) | Predicted damaging (SIFT) |
| c.1789_1791del (p.Lys597del) | In-frame deletion | <0.1% (COSMIC) | Alters kinase domain |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Amplification and overexpression observed in cancers, suggesting oncogenic gain-of-function.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • protein kinase activity | • ATP binding |
| • cell migration | • pseudopodium |
| • cytoskeleton organization |
Pathways
• PEAK family signaling
• Focal adhesion
• Regulation of actin cytoskeleton
Protein Summary
PEAK3 is a 1,200-amino acid pseudokinase that lacks catalytic activity but acts as a scaffold to regulate SRC family kinases and focal adhesion dynamics. It promotes cell migration and invasion, and its overexpression is linked to poor prognosis in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| PEAK3 Knockout HEK293 Cell Line | EDJ-KQ2793 | Human | 374872 | Details Get a Quote |
| PEAK3 Knockout HeLa Cell Line | EDJ-KQ59903 | Human | 374872 | Details Get a Quote |
| PEAK3 Knockout A-549 Cell Line | EDJ-KQ68365 | Human | 374872 | Details Get a Quote |
| PEAK3 Knockout HCT 116 Cell Line | EDJ-KQ76741 | Human | 374872 | Details Get a Quote |
